2024-04-082024-04-082022-10-16Alfaro Lara, V.I., Muñoz Hernández, R., Giménez Miranda, L., Beltrán Romero, L.M., Castell Montsalve, F.J. y Stiefel García-Junco, P.E. (2022). Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients. Journal of Clinical Hypertension, 25 (1), 38-46. https://doi.org/10.1111/jch.14600.1751-7176https://hdl.handle.net/11441/156709Thepancreasfatcontenthasbeenpoorlyinvestigatedinessentialhypertension.Theauthorsaimtorelatepancreasandliverfatcontentwithparametersmeasuringinsulinresistance, beta-cell function and also with markers of endothelial dysfunction andplateletorendothelialcelldestruction.Theauthorsstudiedagroupof40malehyper-tensivepatientswithwell-controlledbloodpressure,maintainingastableweight,andhavingnotchangedtheirmedicationduringthelastyear.Pancreasfatcontentwascor-relatedwithHOMA-IR(r=.616,p<.001),HOMA-S(r=−.439,p<.005),betacellfunctionparameter(r=.457,p<.005),andQUICKI(r=.412,p<.01),whereasliverfatwasnotpatientsinthehighestquartileofpancreasfatcontenthadmorecirculatingendothelialmicroparticlesthanpatientsintheotherquartiles(median129[94.3–200]vs.60.9[49.4–88.8],p=.002).However,patientsinthehighestquartileofthepancreasfat content distribution did not differ from the lowest in hyperemic response afterischemianorcirculatingplateletmicroparticlescount.Liverfatcontentwasnotrelatedto any of the parameters studied. In a multivariate stepwise binary logistic regres-sionanalysis(WaldMethod)circulatingendothelialmicroparticlesremainsignificantlyassociatedwithpancreasfatcontentafteradjustingforconfoundingfactors,suchastobacco,diabetesmellitus,hypercholesterolemia,ormetabolicsyndrome.Ourresultsreflectthatinessentialhypertension,pancreasfatcontentissuperiortoliverfattostudybeta-cellfunctionalityandinsulinresistance.Moreover,theauthorsdescribedforthefirsttimethatpancreasfatcontentisrelatedtoendothelialcelldestruction.Furtherstudiesareneededtoconfirmthispoint.application/pdf8engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/endothelialdysfunctionendothelialmicroparticleHOMApancreasfatcontentQUICKIinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess10.1111/jch.14600