2022-11-302022-11-302022Esteban Ortega, F., Ramos García, P., Muñoz, M. y González Moles, M.Á. (2022). Substance P and Neurokinin 1 Receptor in Chronic Inflammation and Cancer of the Head and Neck: A Review of the Literature. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 19 (1), 375. https://doi.org/10.3390/ijerph19010375.1660-46011661-7827https://hdl.handle.net/11441/139942Head and neck cancer is a growing worldwide public health problem, accounting for approximately 1,500,000 new cases and 500,000 deaths annually. Substance P (SP) is a peptide of the tachykinin family, which has roles related to a large number of physiological mechanisms in humans. The implications of SP in carcinogenesis have recently been reported through the stimulation of the neurokinin 1 receptor (NK1R), or directly, through the effects derived from the constitutive activation of NK1R. Consequently, SP/NK1R seems to play relevant roles in cancer, upregulating cell proliferation, cell migration and chronic inflammation, among other oncogenic actions. Furthermore, there is growing evidence pointing to a central role for SP in tumour progression, singularly so in laryngeal and oral squamous cell carcinomas. The current narrative review of the literature focuses on the relationship between the SP/NK1R system and chronic inflammation and cancer in the head and-neck region. We described a role for SP/NK1R in the transition from chronic inflammation of the head and neck mucosa, to preneoplastic and neoplastic transformation and progression.application/pdf15 p.engAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Substance PNK1RHead and neck cancerSquamous cell carcinomaChronic inflammationinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess10.3390/ijerph19010375