2024-01-312024-01-312011-08Azorín-Ortuño, M., Yáñez-Gascón, M.J., Vallejo, F., Pallarés, F.J., Larrosa, M., Lucas Rodríguez, R.,...,Espín, J.C. (2011). Metabolites and tissue distribution of resveratrol in the pig. Molecular Nutrition and Food Research, 55 (8), 1154-1168. https://doi.org/10.1002/mnfr.201100140.1613-41251613-4133https://hdl.handle.net/11441/154367Scope: trans-Resveratrol (RES) and/(or) its metabolites exert many effects in vivo. Our aim was to study the metabolism and tissue distribution of RES using the pig, a mammal physiologically close to humans. Methods and results: Forty-seven tissues, organs and fluids were analyzed 6h after intragastric RES administration (5.9mg/kg body weight) using HPLC-MS/MS. Twelve RES and seven dihydroresveratrol (DH-RES) metabolites were detected. DH-RES was the main metabolite in cecum, colon and rectum, whereas RES-3-O-glucuronide was the most abundant one in fluids and organs. Approximately 74.5% of the total RES administered was recovered in the form of RES, DH-RES and derived metabolites (65.1% along the gastrointestinal tract, 7.7% in urine, 1.2% in bile and 0.5% in organs). We report here, for the first time, the occurrence of RES ribosyl-sulfate derivative, DH-RES diglucuronide, DH-RES sulfoglucuronide and DH-RES disulfate as well as the metabolic profile of RES and DH-RES in the aorta, lymph, lymph node, ovaries, uterus, cerebellum, pancreas, urinary bladder tissue, fat and muscle. Conclusion: This study contributes to the clarification of the metabolism and tissue distribution of RES and could help to further understand the mechanisms underlying its effects.application/pdf34 p.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/BioavailabilityDihydroresveratrolDispositionMetabolitesPolyphenolinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess10.1002/mnfr.201100140