2025-06-252025-06-252019-04-15Sainz, J., Prieto, C. y Crespo Facorro, B. (2019). Sex differences in gene expression related to antipsychotic induced weight gain. Plos One, 14 (4), e0215477. https://doi.org/10.1371/journal.pone.0215477.1932-6203https://hdl.handle.net/11441/174666Antipsychotics are crucial for the treatment of schizophrenia and contribute to weight gain in psychosis, particularly during early phases. Antipsychotic Induced Weight Gain (AIWG) might contribute to reduce the quality of life, drug compliance and to increase mortality. To characterize sex differences of gene expression related to AIWG, we sequenced total mRNAfrombloodsamplesofschizophrenia patients, before and after 3 months of antipsy chotic-treatment. We analyzed schizophrenia patients according to their sex (38 males and 39 females) and their BMI increase after medication, characterizing the differential gene expression before and after medication. Individuals in each group were categorized in patients who gain weight and those whose do not gain weight. The “weight gain” groups included patients with an increase of body mass index (BMI) > 1.0 points (27 males and 23 females with a median BMI increase of 2.68 and 2.32 respectively). The “no weight gain” groups included patients with a change of BMI between < 1.0 and >-1.0 points (11 males and16females with a median BMIincrease of0.21 and 0.16 respectively). The males had 331geneswith significant differential expression in the weight gain group and 24 genes in the no weight gain group. The females had 119genes with significant differential expression in the weight gain group and 75 genes in the no weight gain group. Both weight gain groups were significantly enriched with “obesity” genes (Fisher; p = 1.1E-09 and p = 0.0001 respec tively), according to the Gene Reference into Function (GeneRIF) database.In conclusion, wecharacterized genes with differential expression associated to AIWG that are specific to males, to females and commonto bothsexes. These genes aregood candidates todepict the biological processes involved in AIWG and provide additional evidence of the genetic links between weight gain and the immune system.application/pdf13 p.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1371/journal.pone.0215477