Article
Combating virulence of Gramnegative bacilli by OmpA inhibition
Author/s | Vila-Farrés, Xavier
Parra Millán, Raquel Sánchez-Encinales, Viviana Varese, Mónica Ayerbe Algaba, Rafael Bayó, Nuria Pachón Díaz, Jerónimo Smani, Younes |
Department | Universidad de Sevilla. Departamento de Medicina |
Publication Date | 2017 |
Deposit Date | 2020-05-14 |
Published in |
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Abstract | Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling
multidrug-resistant bacteria. In this regard, the identifcation of outer membrane protein A (OmpA)
as a key bacterial virulence ... Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling multidrug-resistant bacteria. In this regard, the identifcation of outer membrane protein A (OmpA) as a key bacterial virulence factor has been a major breakthrough. The use of virtual screening helped us to identify a cyclic hexapeptide AOA-2 that inhibits the adhesion of Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli to host cells and the formation of bioflm, thereby preventing the development of infection in vitro and in a murine sepsis peritoneal model. Inhibition of OmpA ofers a strategy as monotherapy to address the urgent need for treatments for infections caused by Gram-negative bacilli. |
Citation | Vila-Farrés, X., Parra Millán, R., Sánchez-Encinales, V., Varese, M., Ayerbe Algaba, R., Bayó, N.,...,Smani, Y. (2017). Combating virulence of Gramnegative bacilli by OmpA inhibition. Scientific Reports, 7 (14683), 1-11. |
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COMBATING VIRULENCE.pdf | 2.636Mb | [PDF] | View/ | |