dc.creator | Ruiz Laza, Rocío | es |
dc.creator | Pérez Villegas, Eva María | es |
dc.creator | Bachiller, Sara | es |
dc.creator | Rosa, José Luis | es |
dc.creator | Armengol, Jose Ángel | es |
dc.date.accessioned | 2020-05-06T06:23:06Z | |
dc.date.available | 2020-05-06T06:23:06Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Ruiz Laza, R., Pérez Villegas, E.M., Bachiller, S., Rosa, J.L. y Armengol, J.Á. (2016). HERC 1 Ubiquitin Ligase Mutation Affects Neocortical, CA3 Hippocampal and Spinal Cord Projection Neurons: An Ultrastructural Study. Frontiers in Neuroanatomy, 10, 42. | |
dc.identifier.issn | 1662-5129 | es |
dc.identifier.uri | https://hdl.handle.net/11441/96176 | |
dc.description.abstract | The spontaneous mutation tambaleante is caused by the Gly483Glu substitution in the
highly conserved N terminal RCC1-like domain of the HERC1 protein, which leads to
the increase of mutated protein levels responsible for cerebellar Purkinje cell death
by autophagy. Until now, Purkinje cells have been the only central nervous neurons
reported as being targeted by the mutation, and their degeneration elicits an ataxic
syndrome in adult mutant mice. | es |
dc.description.sponsorship | MINECO JCI-2011-08888 | es |
dc.description.sponsorship | DGICYT Spanish Government BFU2011-27207 | es |
dc.description.sponsorship | Junta de Andalucía CTS-2257 | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación BFU2011-22498 | es |
dc.description.sponsorship | VPPI-US University of Seville | es |
dc.format | application/pdf | es |
dc.format.extent | 15 p. | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media | es |
dc.relation.ispartof | Frontiers in Neuroanatomy, 10, 42. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Autophagy | es |
dc.subject | Cerebellum | es |
dc.subject | Cerebral cortex | es |
dc.subject | Hippocampus | es |
dc.subject | Neuron | es |
dc.subject | Proteasome | es |
dc.subject | Spinal cord | es |
dc.subject | Ubiquitin | es |
dc.title | HERC 1 Ubiquitin Ligase Mutation Affects Neocortical, CA3 Hippocampal and Spinal Cord Projection Neurons: An Ultrastructural Study | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.relation.projectID | JCI-2011-08888 | es |
dc.relation.projectID | VPPI-US | es |
dc.relation.projectID | BFU2011-27207 | es |
dc.relation.projectID | CTS-2257 | es |
dc.relation.projectID | BFU2011-22498 | es |
dc.relation.publisherversion | https://doi.org/10.3389/fnana.2016.00042 | es |
dc.identifier.doi | 10.3389/fnana.2016.00042 | es |
dc.journaltitle | Frontiers in Neuroanatomy | es |
dc.publication.volumen | 10 | es |
dc.publication.endPage | 42 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | es |
dc.contributor.funder | Universidad de Sevilla | es |
dc.contributor.funder | Dirección General de Investigación Científica y Técnica (DGICYT). España | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |