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dc.creatorMassaro, M.es
dc.creatorRiela, S.es
dc.creatorBaiamonte, C.es
dc.creatorJiménez Blanco, José Luises
dc.creatorGiordano, C.es
dc.creatorLo Meo, Pes
dc.creatorMilioto, S.es
dc.creatorNoto, R.es
dc.date.accessioned2020-04-15T09:07:13Z
dc.date.available2020-04-15T09:07:13Z
dc.date.issued2016
dc.identifier.citationMassaro, M., Riela, S., Baiamonte, C., Jiménez Blanco, J.L., Giordano, C., Lo Meo, P.,...,Noto, R. (2016). Dual drug-loaded halloysite hybrid-based glycocluster for sustained release of hydrophobic molecules. RSC Advances, 91, 87935-87944.
dc.identifier.issn2046-2069es
dc.identifier.urihttps://hdl.handle.net/11441/95220
dc.description.abstractA dual drug-loaded HNT–CD glycocluster delivery system based on halloysite nanotubes and carbohydrate functionalized cyclodextrin was developed by a green protocol using solvent-free microwave irradiation. The nanohybrid was employed for concurrent load and release of silibinin and curcumin. The new delivery system was characterized by means of TGA, FT-IR spectroscopy, SEM and DLS. These techniques confirm the successful loading of the two drugs in the system. SEM and DLS measurements highlighted that the nanomaterial preserves a tubular structure with an average hydrodynamic radius of ca. 200 nm. The release of the drugs from the HNT glycocluster was investigated by means of UV-vis spectroscopy at two different pH values simulanting the typical physiological conditions of either gastric or intestinal fluids. Enzyme-linked lectin assays (ELLA) demonstrated that highly mannoside–cyclodextrins HNT entities display high affinity towards mannose selective ConA lectin. Biological assays showed that the new drug delivery system exhibits anti-proliferative activity against the investigated cell lines. Fluorescence microscopy confirmed ELLA results and it showed a high propensity of this drug delivery system to cross cell membranes and to penetrate into the cell nucleus. The results revealed that the synthesized multicavity system is a material of suitable size and nanoarchitecture to transport drugs into living cells.es
dc.description.sponsorshipSpanish Ministerio de Economia y Competitividad (SAF2013-44021-R)es
dc.formatapplication/pdfes
dc.format.extent10 p.es
dc.language.isoenges
dc.publisherRoyal Society of Chemistryes
dc.relation.ispartofRSC Advances, 91, 87935-87944.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleDual drug-loaded halloysite hybrid-based glycocluster for sustained release of hydrophobic moleculeses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química orgánicaes
dc.relation.projectIDSAF2013-44021-Res
dc.relation.publisherversionhttp://dx.doi.org/10.1039/c6ra14657kes
dc.identifier.doi10.1039/c6ra14657kes
dc.journaltitleRSC Advanceses
dc.publication.issue91es
dc.publication.initialPage87935es
dc.publication.endPage87944es
dc.contributor.funderMinisterio de Economía y Competitividad (MINECO). Españaes

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