dc.creator | Tarancon Diez, Laura | es |
dc.creator | Genebat González, Miguel | es |
dc.creator | Ruiz-Mateos Carmona, Ezequiel | es |
dc.creator | Leal Noval, Manuel | es |
dc.date.accessioned | 2020-03-26T16:40:50Z | |
dc.date.available | 2020-03-26T16:40:50Z | |
dc.date.issued | 2018-07-23 | |
dc.identifier.citation | Tarancon Diez, L., Genebat González, M., Ruiz-Mateos Carmona, E. y Leal Noval, M. (2018). Altered expression of cD300a inhibitory receptor on cD4+ T cells From human immunodeficiency Virus-1-infected Patients: association With Disease Progression Markers. Frontiers in Inmunology., 9, 1-13. | |
dc.identifier.uri | https://hdl.handle.net/11441/94602 | |
dc.description.abstract | The ability of the CD300a inhibitory receptor to modulate immune cell functions and its
involvement in the pathogenesis of many diseases has aroused a great interest in this
molecule. Within human CD4+ T lymphocytes from healthy donors, the inhibitory receptor
CD300a is differentially expressed among different T helper subsets. However, there are
no data about the expression and regulation of CD300a receptor on CD4+ T cells from
human immunodeficiency virus (HIV)-1-infected patients. The objective of this study was
to investigate the expression of CD300a on CD4+ T cells from HIV-infected patients on
suppressive combined antiretroviral therapy (cART) and cART naïve patients. Our results
have demonstrated that the expression levels of this inhibitory receptor were higher on
CD4+ T cells from HIV-1 infected subjects compared with healthy donors, and that cART
did not reverse the altered expression of CD300a receptor in these patients. We have
observed an increase of CD300a expression on both PD1+CD4+ and CD38+CD4+
T cells from HIV-1 infected people. Interestingly, a triple positive (CD300a+PD1+CD38+)
subset was expanded in naïve HIV-1 infected patients, while it was very rare in healthy
donors and patients on cART. Finally, we found a negative correlation of CD300a
expression on CD4+ T lymphocytes and some markers associated with HIV-1 disease
progression. Thus, our results show that HIV-1 infection has an impact in the regulation
of CD300a inhibitory receptor expression levels, and further studies will shed light into the
role of this cell surface receptor in the pathogenesis of HIV infection. | es |
dc.format | application/pdf | es |
dc.format.extent | 13 | es |
dc.language.iso | eng | es |
dc.relation.ispartof | Frontiers in Inmunology., 9, 1-13. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | CD300 | es |
dc.subject | CD300a | es |
dc.subject | human immunodeficiency virus-1 | es |
dc.subject | CD4 T cells | es |
dc.subject | PD1 | es |
dc.title | Altered expression of cD300a inhibitory receptor on cD4+ T cells From human immunodeficiency Virus-1-infected Patients: association With Disease Progression Markers | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina. | es |
dc.relation.projectID | PI13/00889. | es |
dc.relation.projectID | CIG 631674. | es |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fimmu.2018.01709/full | es |
dc.identifier.doi | 10.3389 | es |
dc.journaltitle | Frontiers in Inmunology. | es |
dc.publication.volumen | 9 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 13 | es |
dc.contributor.funder | Plan Estatal de I + D + I, ISCIII-Subdireccion de Evaluacion y Fomento de la Investigacion-Fondo Europeo de Desarrollo Regional (FEDER). | es |
dc.contributor.funder | Marie Curie Actions, Career Integration Grant, European Commission. | es |