Artículo
Cytochrome c signalosome in mitochondria
Autor/es | Díaz Moreno, Irene
García Heredia, José Manuel Díaz Quintana, Antonio Jesús Rosa Acosta, Miguel Ángel de la |
Departamento | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular |
Fecha de publicación | 2011 |
Fecha de depósito | 2019-03-22 |
Publicado en |
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Resumen | Cytochrome c delicately tilts the balance between cell life (respiration) and cell death (apoptosis). Whereas cell life is governed by transient electron transfer interactions of cytochrome c inside the mitochondria, the ... Cytochrome c delicately tilts the balance between cell life (respiration) and cell death (apoptosis). Whereas cell life is governed by transient electron transfer interactions of cytochrome c inside the mitochondria, the cytoplasmic adducts of cytochrome c that lead to cell death are amazingly stable. Interestingly, the contacts of cytochrome c with its counterparts shift from the area surrounding the heme crevice for the redox complexes to the opposite molecule side when the electron flow is not necessary. The cytochrome c signalosome shows a higher level of regulation by post-translational modifications—nitration and phosphorylation—of the hemeprotein. Understanding protein interfaces, as well as protein modifications, would puzzle the mitochondrial cytochrome c-controlled pathways out and enable the design of novel drugs to silence the action of pro-survival and pro-apoptotic partners of cytochrome c. |
Identificador del proyecto | BFU2009-07190
BIO198 P08-CVI-3876 |
Cita | Díaz Moreno, I., García Heredia, J.M., Díaz Quintana, A.J. y Rosa Acosta, M.Á.d.l. (2011). Cytochrome c signalosome in mitochondria. European Biophysics Journal, 40 (12), 1301-1315. |
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Cytochrome c sign.pdf | 615.8Kb | [PDF] | Ver/ | |