Artículo
Cytotoxic activity of methanolic extract and two alkaloids extracted from seeds of Peganum harmala L.
Autor/es | Berrougui, Hicham
López Lázaro, Miguel Martín Cordero, Carmen Mamouchi, Mohamed Ettaib, Abdelkader Herrera González, María Dolores |
Departamento | Universidad de Sevilla. Departamento de Farmacología |
Fecha de publicación | 2005 |
Fecha de depósito | 2017-12-13 |
Publicado en |
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Resumen | To study the cytotoxic activity of P. harmala. Materials and method: The alkaloids harmine and harmaline have been isolated from a methanolic extract from the seeds of P. harmala L. and have been characterized by ... To study the cytotoxic activity of P. harmala. Materials and method: The alkaloids harmine and harmaline have been isolated from a methanolic extract from the seeds of P. harmala L. and have been characterized by spectroscopic-Mass and NMR methods. The cytotoxicity of the methanolic extract and both alkaloids has been investigated in the three human cancer cell lines UACC-62 (melanoma), TK-10 (renal) and MCF-7 (breast) and then compared to the positive control effect of the etoposide. Results and conclusion: The methanolic extract and both alkaloids have inhibited the growth of these three cancer cell-lines and we have discussed possible mechanisms involved in their cytotoxicity. |
Cita | Berrougui, H., López Lázaro, M., Martín Cordero, C., Mamouchi, M., Ettaib, A. y Herrera González, M.D. (2005). Cytotoxic activity of methanolic extract and two alkaloids extracted from seeds of Peganum harmala L.. Journal of Natural Remedies, 5 (1), 41-45. |
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