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dc.creatorRuano Caballero, Diegoes
dc.creatorAraujo, Franciscoes
dc.creatorRevilla Torres, María Elisaes
dc.creatorVela, Josees
dc.creatorBergis, Olivieres
dc.creatorVitorica Ferrández, Francisco Javieres
dc.date.accessioned2017-01-17T08:32:28Z
dc.date.available2017-01-17T08:32:28Z
dc.date.issued2000
dc.identifier.citationRuano Caballero, D., Araujo, F., Revilla Torres, M.E., Vela, J., Bergis, O. y Vitorica Ferrández, F.J. (2000). GABAa and a-Amino-3-hydroxy-5-methylsoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampus. Journal of Biological Chemistry, 275 (26), 19585-19593.
dc.identifier.issn0021-9258es
dc.identifier.urihttp://hdl.handle.net/11441/52315
dc.description.abstractWe have investigated the age-dependent modifications in the expression of eight different subunits of the γ-aminobutyric acid, type A (GABAA) receptor (α1, α2, α3, α5, β2, β3, γ2S, and γ2L) and all four subunits of the α-amino-3-hydroxy-5-methylsoxazole-4-propionate (AMPA) receptor (GluR1–4) in the hippocampus of 24-month-old rats. All aged hippocampi displayed a remarkable increase (aged/adult ratio, 3.53 ± 0.54) in the mRNA levels of the short version of the γ2 subunit in parallel with a similar increase in the γ2 subunit protein (aged/adult ratio, 2.90 ± 0.62). However, this increase was not observed in the mature receptor. On the other hand, the expression of the different α subunit mRNAs increased moderately with aging, displaying a heterogeneous pattern. The most frequent modification consisted in an increase in the expression of the α1 subunit mRNA (aged/adult ratio, 1.26 ± 0.18), in parallel with a similar increase on the α1 protein (aged/adult ratio, 1.27 ± 0.12) and in the α1 incorporated to the assembled GABAA receptor (tested by immunoprecipitation; aged/adult ratio, = 1.20 ± 0.10). However, in the same hippocampal samples, no major modifications were observed on the expression of the AMPA receptor subunits. As a whole, these results indicated the existence of an increased expression of the GABAA receptor subunits and a preservation of the AMPA receptor at the hippocampal formation. These modifications could reflect the existence of specific deficiencies (neuronal loss and/or deafferentiation) on the GABAergic system in the aged ratses
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherAmerican Society for Biochemistry and Molecular Biologyes
dc.relation.ispartofJournal of Biological Chemistry, 275 (26), 19585-19593.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleGABAa and a-Amino-3-hydroxy-5-methylsoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampuses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica y Biología Moleculares
dc.identifier.doi10.1074/jbc.M000700200es
idus.format.extent10 p.es
dc.journaltitleJournal of Biological Chemistryes
dc.publication.volumen275es
dc.publication.issue26es
dc.publication.initialPage19585es
dc.publication.endPage19593es

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