dc.creator | Trujillo Estrada, Laura Isabel | es |
dc.creator | Jiménez Muñoz, Sebastián | es |
dc.creator | Castro, Vanessa de | es |
dc.creator | Torres Canalejo, Manuel | es |
dc.creator | Baglietto Vargas, David | es |
dc.creator | Moreno González, Inés | es |
dc.creator | Navarro Garrido, Victoria | es |
dc.creator | Sánchez Varo, Raquel María | es |
dc.creator | Sánchez Mejías, Elisabeth | es |
dc.creator | Dávila Cansino, José Carlos | es |
dc.creator | Vizuete Chacón, María Luisa | es |
dc.creator | Gutiérrez Pérez, Antonia | es |
dc.creator | Vitorica Ferrández, Francisco Javier | es |
dc.date.accessioned | 2016-12-16T11:41:40Z | |
dc.date.available | 2016-12-16T11:41:40Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Trujillo Estrada, L.I., Jiménez Muñoz, S., Castro, V.d., Torres Canalejo, M., Baglietto Vargas, D., Moreno González, I.,...,Vitorica Ferrández, F.J. (2013). In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology. Acta neuropathologica communications, 1 (1), 73. | |
dc.identifier.issn | 2051-5960 | es |
dc.identifier.uri | http://hdl.handle.net/11441/50590 | |
dc.description.abstract | Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies, neuronal loss and the deterioration of cognitive capabilities of patients. However, no effective disease-modifying treatment has been yet developed. In this work we have evaluated whether chronic lithium treatment could ameliorate the neuropathology evolution of our well characterized PS1M146LxAPPSwe-London mice model.
Results: Though beneficial effects of lithium have been previously described in different AD models, here we report a novel in vivo action of this compound that efficiently ameliorated AD-like pathology progression and rescued memory impairments by reducing the toxicity of Abeta plaques. Transgenic PS1M146LxAPPSwe-London mice, treated before the pathology onset, developed smaller plaques characterized by higher Abeta compaction, reduced oligomeric-positive halo and therefore with attenuated capacity to induce neuronal damage. Importantly, neuronal loss in hippocampus and entorhinal cortex was fully prevented. Our data also demonstrated that the axonal
dystrophic area associated with lithium-modified plaques was highly reduced. Moreover, a significant lower accumulation
of phospho-tau, LC3-II and ubiquitinated proteins was detected in treated mice. Our study highlights that this switch of plaque quality by lithium could be mediated by astrocyte activation and the release of heat shock proteins, which concentrate in the core of the plaques.
Conclusions: Our data demonstrate that the pharmacological in vivo modulation of the extracellular Abeta plaque compaction/toxicity is indeed possible and, in addition, might constitute a novel promising and
innovative approach to develop a disease-modifying therapeutic intervention against AD. | es |
dc.description.sponsorship | Istituto de Salud Carlos III PI12/01439 y PI12/01431 | es |
dc.description.sponsorship | CIBERNED PI2010/08 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | BioMed Central | es |
dc.relation.ispartof | Acta neuropathologica communications, 1 (1), 73. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Alzheimer | es |
dc.subject | Lithium treatment | es |
dc.subject | Transgenic mice | es |
dc.subject | Neuronal degeneration | es |
dc.subject | Axonal dystrophies | es |
dc.subject | Abeta plaques | es |
dc.subject | Toxicity | es |
dc.title | In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.relation.projectID | PI12/01439 | es |
dc.relation.projectID | PI12/01431 | es |
dc.relation.projectID | PI2010/08 | es |
dc.relation.publisherversion | 10.1186/2051-5960-1-73 | es |
dc.relation.publisherversion | http://dx.doi.org/10.1186/2051-5960-1-73 | es |
dc.identifier.doi | 10.1186/2051-5960-1-73 | es |
idus.format.extent | 16 p. | es |
dc.journaltitle | Acta neuropathologica communications | es |
dc.publication.volumen | 1 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 73 | es |
dc.contributor.funder | Instituto de Salud Carlos III | |