dc.creator | Rodríguez Morgado, Bruno | es |
dc.creator | Candiracci, Manila | es |
dc.creator | Santa-María Pérez, Consuelo | es |
dc.creator | Revilla Torres, María Elisa | es |
dc.creator | Gordillo Arrobas, Belén | es |
dc.creator | Parrado Rubio, Juan | es |
dc.creator | Castaño Navarro, Angélica | es |
dc.date.accessioned | 2016-06-06T10:35:33Z | |
dc.date.available | 2016-06-06T10:35:33Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Rodríguez Morgado, B., Candiracci, M., Santa-María Pérez, C., Revilla Torres, M.E., Gordillo Arrobas, B., Parrado Rubio, J. y Castaño Navarro, A. (2015). Obtaining from grape pomace an enzymatic extract with anti-inflammatory properties. Plant Foods for Human Nutrition, 70, 42-49. | |
dc.identifier.issn | 0921-9668 | es |
dc.identifier.uri | http://hdl.handle.net/11441/41902 | |
dc.description.abstract | Grape pomace, a winemaking industry by-product,
is a rich source of bioactive dietary compounds. Using proteases
we have developed an enzymatic process for obtaining a
water-soluble extract (GP-EE) that contains biomolecules
such as peptides, carbohydrates, lipids and polyphenols in
soluble form. Of especial interest is its high polyphenol content
(12 %), of which 77 % are flavonoids and 33 % are
phenolic acids. The present study evaluates in vitro the potential
anti-inflammatory effect of GP-EE by monitoring the
expression of inflammatory molecules on N13 microglia cells
stimulated with lipopolysaccharide (LPS). GP-EE decreases
the mRNA levels of the inflammatory molecules studied. The
molecules under study were as follows: inducible nitric oxide
synthase (iNOS), tumor necrosis factor- α (TNF-α),
interleukin-1β (IL-1β), the ionized calcium binding adaptor
molecule-1(Iba-1) and the Toll like receptor-4 (TLR-4), as
well as the iNOS protein level in LPS-stimulated microglia.
Our findings suggest that, as a result of its ability to regulate
excessive microglial activation, GP-EE possesses antiinflammatory
properties. Therefore, acting as a chemopreventive
agent, it may be of therapeutic interest in neurodegenerative
diseases involving neuroinflammation. We can,
therefore, propose GP-EE as a useful natural extract and one
that would be beneficial to apply in the field of functional
foods | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Springer Netherlands | es |
dc.relation.ispartof | Plant Foods for Human Nutrition, 70, 42-49. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Enzymatic extract | es |
dc.subject | Polyphenols | es |
dc.subject | Anti-inflammatory | es |
dc.subject | Neurodegeneration | es |
dc.subject | Grape pomace | es |
dc.title | Obtaining from grape pomace an enzymatic extract with anti-inflammatory properties | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.relation.publisherversion | 10.1007/s11130-014-0459-0 | es |
dc.identifier.doi | http://dx.doi.org/10.1007/s11130-014-0459-0 | es |
idus.format.extent | 8 p. | es |
dc.journaltitle | Plant Foods for Human Nutrition | es |
dc.publication.volumen | 70 | es |
dc.publication.initialPage | 42 | es |
dc.publication.endPage | 49 | es |
dc.identifier.idus | https://idus.us.es/xmlui/handle/11441/41902 | |