Mostrar el registro sencillo del ítem
Artículo
Long-term outcome of patients after a single interruption of antiretroviral therapy: a cohort study
dc.creator | Machado, Carmen | es |
dc.creator | Ríos-Villegas, María José | es |
dc.creator | Gálvez-Acebal, Juan | es |
dc.creator | Domínguez Castellano, Angel | es |
dc.creator | Fernández-Cuenca, Felipe | es |
dc.creator | Palomo, Virginia | es |
dc.creator | Muniain Ezcurra, Miguel Angel | es |
dc.creator | Rodríguez-Baño, Jesús | es |
dc.date.accessioned | 2016-04-26T18:54:09Z | |
dc.date.available | 2016-04-26T18:54:09Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1756-0500 | es |
dc.identifier.uri | http://hdl.handle.net/11441/40493 | |
dc.description.abstract | Background: To describe the long term outcome of patients who interrupted highly active antiretroviral therapy (HAART) once, identify the variables associated with earlier need to re-start HAART, and the response when therapy was resumed. A retrospective observational cohort of 66 adult patients with HIV-1 infection who interrupted HAART with a CD4+cell count ≥350 cells/μL and undetectable viral load (VL) was performed. The pre-established CD4+ cell count for restarting therapy was 300cells/μL. Cox regression was used to analyse the variables associated with earlier HAART reinitiation. Results: The median follow-up was 209 weeks (range, 64–395). Rates of HIV-related or possible HIV-related events were 0.37 (one case of acute retroviral syndrome) and 1.49 per 100 patient-years, respectively. Two patients died after re-starting therapy and having reached undetectable VL. Three patients suffered a sexually transmitted disease while off therapy. Fifty patients (76%) resumed therapy after a median of 97 weeks (range, 17–267). Age, a nadir of CD4+ <250 cells/μL, and a mean VL during interruption of >10,000 copies/ml were independent predictors for earlier re-start. The intention-to-treat success rate of the first HAART resumed regimen was 85.4%. There were no differences by regimen used, nor between regimens that were the same as or different from the one that had been interrupted. Conclusions: Our data suggest highly active antiretroviral therapy may be interrupted in selected patients because in these patients, when the HAART is restarted, the viral and clinical response may be achieved. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | BioMed Central | es |
dc.relation.ispartof | BMC Research Notes, 5, 578-586 | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | HIV-1 | es |
dc.subject | Antiretroviral therapy | es |
dc.subject | Treatment interruption | es |
dc.subject | Outcome | es |
dc.subject | Cohort study | es |
dc.subject | Fármacos anti-VIH | es |
dc.subject | Infecciones por VIH | es |
dc.title | Long-term outcome of patients after a single interruption of antiretroviral therapy: a cohort study | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | http://www.biomedcentral.com/1756-0500/5/578/abstract | es |
dc.identifier.doi | http://dx.doi.org/10.1186/1756-0500-5-578 | es |
idus.format.extent | 8 | es |
dc.identifier.idus | https://idus.us.es/xmlui/handle/11441/40493 |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
20424583.pdf | 557.3Kb | [PDF] | Ver/ | |