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dc.creatorGonzález Rodríguez, María Luisa
dc.creatorRabasco Álvarez, Antonio María
dc.creatorLópez Cacho, José Manuel
dc.creatorGallardo, Soledad
dc.creatorPosada, Manuel
dc.creatorAguerri, Miriam
dc.creatorCalzada, David
dc.creatorMayayo, Teodoro
dc.creatorLahoz, Carlos
dc.creatorCárdaba, Blanca
dc.date.accessioned2016-03-11T09:10:09Z
dc.date.available2016-03-11T09:10:09Z
dc.date.issued2014
dc.identifier.issn2314-6133es
dc.identifier.urihttp://hdl.handle.net/11441/38399
dc.description.abstractThis study aimed to search the correlation among immunological profiles and clinical phenotypes of scleroderma in well- characterized groups of scleroderma patients, comparing forty-nine scleroderma patients stratified according to specific clinical phenotypes with forty-nine healthy controls. Five immunological cell subpopulations (B, CD4+ and CD8+ T-cells, NK, and monocytes) and their respective stages of apoptosis and activation were analyzed by flow cytometry, in samples of peripheral blood mononuclear cells (PBMCs). Analyses of results were stratified according to disease stage, time since the diagnosis, and visceral damage (pulmonary fibrosis, pulmonary hypertension, and cardiac affliction) and by time of treatment with corticosteroids. An increase in the percentages of monocytes and a decrease in the B cells were mainly related to the disease progression. A general apoptosis decrease was found in all phenotypes studied, except in localized scleroderma. An increase of B and NK cells activation was found in patients diagnosed more than 10 years ago. Specific cell populations like monocytes, NK, and B cells were associated with the type of affected organ. This study shows how, in a heterogeneous disease, proper patient’s stratification according to clinical phenotypes allows finding specific cellular profiles. Our data may lead to improvements in the knowledge of prognosis factors and to aid in the analysis of future specific therapies.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherHindawi Publishing Corporationes
dc.relation.ispartofBioMed Research International, 2014,  148293es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCorticosteroides
dc.subjectMethylprednisolonees
dc.subjectPrednisonees
dc.titleAssociation of immunological cell profiles with specific clinical phenotypes of scleroderma diseasees
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéuticaes
dc.relation.publisherversion10.1155/2014/148293es
dc.identifier.doihttp://dx.doi.org/10.1155/2014/148293es
dc.identifier.idushttps://idus.us.es/xmlui/handle/11441/38399

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