Artículo
HmbC, a Protein of the HMG Family, Participates in the Regulation of Carotenoid Biosynthesis in Fusarium fujikuroi
Autor/es | Franco Losilla, Marta
Nordzieke, Steffen Feldmann, Ingo Limón Mirón, María del Carmen Ávalos Cordero, Francisco Javier |
Departamento | Universidad de Sevilla. Departamento de Genética |
Fecha de publicación | 2023 |
Fecha de depósito | 2023-09-12 |
Publicado en |
|
Resumen | In the fungus Fusarium fujikuroi, carotenoid production is up-regulated by light and down-regulated by the CarS RING finger protein, which modulates the mRNA levels of carotenoid pathway genes (car genes). To identify new ... In the fungus Fusarium fujikuroi, carotenoid production is up-regulated by light and down-regulated by the CarS RING finger protein, which modulates the mRNA levels of carotenoid pathway genes (car genes). To identify new potential regulators of car genes, we used a biotin-mediated pull-down procedure to detect proteins capable of binding to their promoters. We focused our attention on one of the proteins found in the screening, belonging to the High-Mobility Group (HMG) family that was named HmbC. The deletion of the hmbC gene resulted in increased carotenoid production due to higher mRNA levels of car biosynthetic genes. In addition, the deletion resulted in reduced carS mRNA levels, which could also explain the partial deregulation of the carotenoid pathway. The mutants exhibited other phenotypic traits, such as alterations in development under certain stress conditions, or reduced sensitivity to cell wall degrading enzymes, revealed by less efficient protoplast formation, indicating that HmbC is also involved in other cellular processes. In conclusion, we identified a protein of the HMG family that participates in the regulation of carotenoid biosynthesis. This is probably achieved through an epigenetic mechanism related to chromatin structure, as is frequent in this class of proteins. |
Agencias financiadoras | Ministerio de Economía y Competitividad (MINECO). España Ministerio de Ciencia e Innovación (MICIN). España Junta de Andalucía |
Identificador del proyecto | BIO 2015–69613-R
RTI 2018-101902-B-I00 P10-CTS-6638 P20-01243 |
Cita | Franco Losilla, M., Nordzieke, S., Feldmann, I., Limón Mirón, M.d.C. y Ávalos Cordero, F.J. (2023). HmbC, a Protein of the HMG Family, Participates in the Regulation of Carotenoid Biosynthesis in Fusarium fujikuroi. Genes, 14 (8), 1661. https://doi.org/10.3390/genes14081661. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
HmbC a Protein.pdf | 4.529Mb | [PDF] | Ver/ | |