dc.creator | Claro Cala, Carmen María | es |
dc.creator | Grao Cruces, Elena | es |
dc.creator | Toscano Sánchez, María del Rocío | es |
dc.creator | Millán-Linares, María del Carmen | es |
dc.creator | Montserrat de la Paz, Sergio | es |
dc.creator | Martín Rubio, María Esther | es |
dc.date.accessioned | 2023-06-20T13:55:20Z | |
dc.date.available | 2023-06-20T13:55:20Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Claro Cala, C.M., Grao Cruces, E., Toscano Sánchez, M.d.R., Millán-Linares, M.d.C., Montserrat de la Paz, S. y Martín Rubio, M.E. (2022). Acyclic Diterpene Phytol from Hemp Seed Oil (Cannabis sativa L.) Exerts Anti-Inflammatory Activity on Primary Human Monocytes-Macrophages. Foods, 11 (15), 2366. https://doi.org/10.3390/foods11152366. | |
dc.identifier.issn | 2304-8158 | es |
dc.identifier.uri | https://hdl.handle.net/11441/147362 | |
dc.description.abstract | Seeds from non-drug varieties of hemp (Cannabis sativa L.) have been used for traditional
medicine, food, and fiber production. Our study shows that phytol obtained from hemp seed oil
(HSO) exerts anti-inflammatory activity in human monocyte-macrophages. Fresh human monocytes
and human macrophages derived from circulating monocytes were used to evaluate both plasticity
and anti-inflammatory effects of phytol from HSO at 10–100 mM using FACS analysis, ELISA, and
RT-qPCR methods. The quantitative study of the acyclic alcohol fraction isolated from HSO shows
that phytol is the most abundant component (167.59 ± 1.81 mg/Kg of HSO). Phytol was able to
skew monocyte-macrophage plasticity toward the anti-inflammatory non-classical CD14+CD16++
monocyte phenotype and toward macrophage M2 (CD200Rhigh and MRC-1high), as well as to reduce
the production of IL-1β, IL-6, and TNF-α, diminishing the inflammatory competence of mature
human macrophages after lipopolysaccharide (LPS) treatment. These findings point out for the first
time the reprogramming and anti-inflammatory activity of phytol in human monocyte-macrophages.
In addition, our study may help to understand the mechanisms by which phytol from HSO contributes
to the constant and progressive plasticity of the human monocyte-macrophage linage. | es |
dc.format | application/pdf | es |
dc.format.extent | 12 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Foods, 11 (15), 2366. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Phytol | es |
dc.subject | Nutraceuticals | es |
dc.subject | Unsaponifiable | es |
dc.subject | Hemp seed oil | es |
dc.subject | Functional foods | es |
dc.subject | Immunonutrition | es |
dc.title | Acyclic Diterpene Phytol from Hemp Seed Oil (Cannabis sativa L.) Exerts Anti-Inflammatory Activity on Primary Human Monocytes-Macrophages | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología, Pediatría y Radiología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Celular | es |
dc.relation.publisherversion | https://www.mdpi.com/2304-8158/11/15/2366 | es |
dc.identifier.doi | 10.3390/foods11152366 | es |
dc.journaltitle | Foods | es |
dc.publication.volumen | 11 | es |
dc.publication.issue | 15 | es |
dc.publication.initialPage | 2366 | es |