dc.creator | Claro Cala, Carmen María | es |
dc.creator | Jiménez Altayó, Francesc | es |
dc.creator | Zagmutt, Sebastián | es |
dc.creator | Rodríguez Rodríguez, Rosalía | es |
dc.date.accessioned | 2023-05-24T13:21:15Z | |
dc.date.available | 2023-05-24T13:21:15Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Claro Cala, C.M., Jiménez Altayó, F., Zagmutt, S. y Rodríguez Rodríguez, R. (2022). Molecular Mechanisms Underlying the Effects of Olive Oil Triterpenic Acids in Obesity and Related Diseases. Nutrients, 14 (8), 1606. https://doi.org/10.3390/nu14081606. | |
dc.identifier.issn | 2072-6643 | es |
dc.identifier.uri | https://hdl.handle.net/11441/146589 | |
dc.description.abstract | Dietary components exert protective effects against obesity and related metabolic and
cardiovascular disturbances by interfering with the molecular pathways leading to these pathologies.
Dietary biomolecules are currently promising strategies to help in the management of obesity and
metabolic syndrome, which are still unmet medical issues. Olive oil, a key component of the
Mediterranean diet, provides an exceptional lipid matrix highly rich in bioactive molecules. Among
them, the pentacyclic triterpenic acids (i.e., oleanolic acid) have gained clinical relevance in the
last decade due to their wide range of biological actions, particularly in terms of vascular function,
obesity and insulin resistance. Considering the promising effects of these triterpenic compounds
as nutraceuticals and components of functional foods against obesity and associated complications,
the aim of our review is to decipher and discuss the main molecular mechanisms underlying these
effects driven by olive oil triterpenes, in particular by oleanolic acid. Special attention is paid to their
signaling and targets related to glucose and insulin homeostasis, lipid metabolism, adiposity and
cardiovascular dysfunction in obesity. Our study is aimed at providing a better understanding of
the impact of dietary components of olive oil in the long-term management of obesity and metabolic
syndrome in humans. | es |
dc.format | application/pdf | es |
dc.format.extent | 17 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Nutrients, 14 (8), 1606. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Triterpenes | es |
dc.subject | Olive oil | es |
dc.subject | Obesity | es |
dc.subject | Insulin resistance | es |
dc.subject | Adiposity | es |
dc.subject | Vascular diseases | es |
dc.subject | Oleanolic acid | es |
dc.title | Molecular Mechanisms Underlying the Effects of Olive Oil Triterpenic Acids in Obesity and Related Diseases | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología, Pediatría y Radiología | es |
dc.relation.projectID | PID2020- 114953RB-C22 | es |
dc.relation.projectID | PID2020-113634RB-C22 | es |
dc.relation.projectID | PCI2018-092997 | es |
dc.relation.publisherversion | https://www.mdpi.com/2072-6643/14/8/1606 | es |
dc.identifier.doi | 10.3390/nu14081606 | es |
dc.contributor.group | Universidad de Sevilla. CTS605: Farmacología: Neurodegeneración y neuroprotección. | es |
dc.journaltitle | Nutrients | es |
dc.publication.volumen | 14 | es |
dc.publication.issue | 8 | es |
dc.publication.initialPage | 1606 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es |
dc.contributor.funder | Agencia Estatal de Investigación. España | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |