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Article
RMRP, RMST, FTX and IPW: novel potential long non-coding RNAs in medullary thyroid cancer
Author/s | Luzón-Toro, Berta
Villalba Benito, Leticia Fernández, Raquel María Torroglosa, Ana Antiñolo Gil, Guillermo Borrego, Salud |
Department | Universidad de Sevilla. Departamento de Cirugía |
Publication Date | 2021 |
Deposit Date | 2022-07-28 |
Published in |
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Abstract | The relevant role of long non-coding RNAs (lncRNAs) in cancer is currently a matter of increasing interest. Medullary thyroid cancer (MTC) is a rare neuroendocrine tumor (2–5% of all thyroid cancer) derived from the ... The relevant role of long non-coding RNAs (lncRNAs) in cancer is currently a matter of increasing interest. Medullary thyroid cancer (MTC) is a rare neuroendocrine tumor (2–5% of all thyroid cancer) derived from the parafollicular C-cells which secrete calcitonin. About 75% of all medullary thyroid cancers are believed to be sporadic medullary thyroid cancer (sMTC), whereas the remaining 25% correspond to inherited cancer syndromes known as Multiple Endocrine Neoplasia type 2 (MEN2). MEN2 syndrome, with autosomal dominant inheritance is caused by germline gain of function mutations in RET proto-oncogene. To date no lncRNA has been associated to MEN2 syndrome and only two articles have been published relating long non-coding RNA (lncRNA) to MTC: the first one linked MALAT1 with sMTC and, in the other, our group determined some new lncRNAs in a small group of sMTC cases in fresh tissue (RMST, FTX, IPW, PRNCR1, ADAMTS9-AS2 and RMRP). The aim of the current study is to validate such novel lncRNAs previously described by our group by using a larger cohort of patients, in order to discern their potential role in the disease. Here we have tested three up-regulated (RMST, FTX, IPW) and one down-regulated (RMRP) lncRNAs in our samples (formalin fixed paraffin embedded tissues from twenty-one MEN2 and ten sMTC patients) by RT-qPCR analysis. The preliminary results reinforce the potential role of RMST, FTX, IPW and RMRP in the pathogenesis of MTC. |
Project ID. | PT13/0010/0056
PI16/0142 PI19/01550 PEER‑0470–2019 |
Citation | Luzón-Toro, ., Villalba Benito, L., Fernández, R.M., Torroglosa, A., Antiñolo Gil, G. y Borrego, S. (2021). RMRP, RMST, FTX and IPW: novel potential long non-coding RNAs in medullary thyroid cancer. ORPHANET JOURNAL OF RARE DISEASES, 16 (4) |
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