dc.creator | Evangelista, Tereza Cristina Santos | es |
dc.creator | López López, Óscar | es |
dc.creator | Ferreira, Sabrina Baptista | es |
dc.creator | Fernández-Bolaños Guzmán, José María | es |
dc.creator | Sydnes, Magne O. | es |
dc.creator | Lindbäck, Emil | es |
dc.date.accessioned | 2022-04-07T12:33:25Z | |
dc.date.available | 2022-04-07T12:33:25Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Evangelista, T.C.S., López López, Ó., Ferreira, S.B., Fernández-Bolaños Guzmán, J.M., Sydnes, M.O. y Lindbäck, E. (2021). Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase. Journal of Enzyme Inhibition and Medicinal Chemistry, 36 (1), 1659-1664. | |
dc.identifier.issn | 1475-6366 | es |
dc.identifier.issn | 1475-6374 | es |
dc.identifier.uri | https://hdl.handle.net/11441/131938 | |
dc.description.abstract | The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described. The multivalent inhibition potencies for the tacrine clusters were investigated for the inhibition of acetylcholinesterase. Two of the tacrine clusters displayed a small but significant multivalent inhibition potency in which the binding affinity of each of the tacrine binding units increased up to 3.2 times when they are connected to the central scaffold. | es |
dc.description.sponsorship | Junta de Andalucía. FQM134 | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación de España (MICINN) y fondos FEDER de la Unión Europea. CTQ2016-78703-P | es |
dc.format | application/pdf | es |
dc.format.extent | 6 p. | es |
dc.language.iso | eng | es |
dc.publisher | Taylor & Francis Open Access | es |
dc.relation.ispartof | Journal of Enzyme Inhibition and Medicinal Chemistry, 36 (1), 1659-1664. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Acetylcholinesterase | es |
dc.subject | CuAAC | es |
dc.subject | multivalent interactions | es |
dc.subject | multivalent inhibition potency | es |
dc.subject | tacrine | es |
dc.title | Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Electrónica y Electromagnetismo | es |
dc.relation.projectID | FQM134 | es |
dc.relation.projectID | CTQ2016-78703-P | es |
dc.relation.publisherversion | https://doi.org/10.1080/14756366.2021.1954917 | es |
dc.identifier.doi | 10.1080/14756366.2021.1954917 | es |
dc.contributor.group | Universidad de Sevilla. FQM134: Química Fina de Carbohidratos | es |
dc.journaltitle | Journal of Enzyme Inhibition and Medicinal Chemistry | es |
dc.publication.volumen | 36 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 1659 | es |
dc.publication.endPage | 1664 | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | Universidad de Stavanger. Noruega | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |