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Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase

dc.creatorEvangelista, Tereza Cristina Santoses
dc.creatorLópez López, Óscares
dc.creatorFerreira, Sabrina Baptistaes
dc.creatorFernández-Bolaños Guzmán, José Maríaes
dc.creatorSydnes, Magne O.es
dc.creatorLindbäck, Emiles
dc.date.accessioned2022-04-07T12:33:25Z
dc.date.available2022-04-07T12:33:25Z
dc.date.issued2021
dc.identifier.citationEvangelista, T.C.S., López López, Ó., Ferreira, S.B., Fernández-Bolaños Guzmán, J.M., Sydnes, M.O. y Lindbäck, E. (2021). Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase. Journal of Enzyme Inhibition and Medicinal Chemistry, 36 (1), 1659-1664.
dc.identifier.issn1475-6366es
dc.identifier.issn1475-6374es
dc.identifier.urihttps://hdl.handle.net/11441/131938
dc.description.abstractThe synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described. The multivalent inhibition potencies for the tacrine clusters were investigated for the inhibition of acetylcholinesterase. Two of the tacrine clusters displayed a small but significant multivalent inhibition potency in which the binding affinity of each of the tacrine binding units increased up to 3.2 times when they are connected to the central scaffold.es
dc.description.sponsorshipJunta de Andalucía. FQM134es
dc.description.sponsorshipMinisterio de Ciencia e Innovación de España (MICINN) y fondos FEDER de la Unión Europea. CTQ2016-78703-Pes
dc.formatapplication/pdfes
dc.format.extent6 p.es
dc.language.isoenges
dc.publisherTaylor & Francis Open Accesses
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistry, 36 (1), 1659-1664.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAcetylcholinesterasees
dc.subjectCuAACes
dc.subjectmultivalent interactionses
dc.subjectmultivalent inhibition potencyes
dc.subjecttacrinees
dc.titleDevelopment of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterasees
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Electrónica y Electromagnetismoes
dc.relation.projectIDFQM134es
dc.relation.projectIDCTQ2016-78703-Pes
dc.relation.publisherversionhttps://doi.org/10.1080/14756366.2021.1954917es
dc.identifier.doi10.1080/14756366.2021.1954917es
dc.contributor.groupUniversidad de Sevilla. FQM134: Química Fina de Carbohidratoses
dc.journaltitleJournal of Enzyme Inhibition and Medicinal Chemistryes
dc.publication.volumen36es
dc.publication.issue1es
dc.publication.initialPage1659es
dc.publication.endPage1664es
dc.contributor.funderJunta de Andalucíaes
dc.contributor.funderUniversidad de Stavanger. Noruegaes
dc.contributor.funderMinisterio de Ciencia e Innovación (MICIN). Españaes
dc.contributor.funderEuropean Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)es

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