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dc.creatorEl Hammadi, Mazen M.es
dc.creatorArias, José L.es
dc.date.accessioned2022-03-25T10:47:15Z
dc.date.available2022-03-25T10:47:15Z
dc.date.issued2022
dc.identifier.citationEl Hammadi, M.M. y Arias, J.L. (2022). Recent Advances in the Surface Functionalization of PLGA-Based Nanomedicines. Nanomaterials, 12 (3), 354.
dc.identifier.issn2079-4991es
dc.identifier.urihttps://hdl.handle.net/11441/131285
dc.description.abstractTherapeutics are habitually characterized by short plasma half-lives and little affinity for targeted cells. To overcome these challenges, nanoparticulate systems have entered into the disease arena. Poly(d,l-lactide-co-glycolide) (PLGA) is one of the most relevant biocompatible materials to construct drug nanocarriers. Understanding the physical chemistry of this copolymer and current knowledge of its biological fate will help in engineering efficient PLGA-based nanomedicines. Surface modification of the nanoparticle structure has been proposed as a required functionalization to optimize the performance in biological systems and to localize the PLGA colloid into the site of action. In this review, a background is provided on the properties and biodegradation of the copolymer. Methods to formulate PLGA nanoparticles, as well as their in vitro performance and in vivo fate, are briefly discussed. In addition, a special focus is placed on the analysis of current research in the use of surface modification strategies to engineer PLGA nanoparticles, i.e., PEGylation and the use of PEG alternatives, surfactants and lipids to improve in vitro and in vivo stability and to create hydrophilic shells or stealth protection for the nanoparticle. Finally, an update on the use of ligands to decorate the surface of PLGA nanomedicines is included in the review.es
dc.formatapplication/pdfes
dc.format.extent34 p.es
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofNanomaterials, 12 (3), 354.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectactive drug targetinges
dc.subjectligand-mediated targetinges
dc.subjectnanoparticlees
dc.subjectpassive drug targetinges
dc.subjectPLGAes
dc.subjectstealth coatinges
dc.subjectsurface functionalizationes
dc.titleRecent Advances in the Surface Functionalization of PLGA-Based Nanomedicineses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéuticaes
dc.relation.publisherversionhttp://dx.doi.org/10.3390/nano12030354es
dc.identifier.doi10.3390/nano12030354es
dc.contributor.groupUniversidad de Sevilla CTS480: Investigación y Desarrollo Tecnológico en Nanomedicinaes
dc.journaltitleNanomaterialses
dc.publication.volumen12es
dc.publication.issue3es
dc.publication.endPage354es

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Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional