dc.creator | Grothe, Michel J. | es |
dc.creator | Labrador-Espinosa, Miguel Á. | es |
dc.creator | Silvia, Jesús | es |
dc.creator | Macías-García, Daniel | es |
dc.creator | Adarmes-Gómez, Astrid | es |
dc.creator | Carrillo, Fátima | es |
dc.creator | Iglesias Camacho, Elena | es |
dc.creator | Franco-Rosado, Pablo | es |
dc.creator | Roldán Lora, Florinda | es |
dc.creator | Martin Rodríguez, Juan Francisco | es |
dc.creator | Mir Rivera, Pablo | es |
dc.creator | Aguilar Barberá, Miquel | es |
dc.creator | Escalante Arroyo, Sonia | es |
dc.creator | Solano Vila, Berta | es |
dc.creator | de Deus Fonticoba, Teresa | es |
dc.creator | Carrillo Padilla, Francisco | es |
dc.creator | Infante Ceberio, Jon | es |
dc.creator | Hernández Vara, Jorge | es |
dc.creator | de Fábregues Boixar, Oriol | es |
dc.creator | Kulisevsky, Jaime | es |
dc.creator | Martínez Martín, Pablo | es |
dc.creator | Santos García, Diego | es |
dc.creator | Pastor, Pau | es |
dc.creator | Ruíz Martínez, Javier | es |
dc.creator | Cots Foraster, Anna | es |
dc.creator | Pueyo Morlans, Mercedes | es |
dc.creator | Pascual Sedano, Berta | es |
dc.creator | González Aramburu, Isabel | es |
dc.date.accessioned | 2021-12-02T12:43:50Z | |
dc.date.available | 2021-12-02T12:43:50Z | |
dc.date.issued | 2021-05-31 | |
dc.identifier.citation | Grothe, M.J., Labrador-Espinosa, M.Á., Silvia, J., Macías-García, D., Adarmes-Gómez, A., Carrillo, F.,...,González Aramburu, I. (2021). In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study. Parkinsonism & Related Disorders, 88, 68-75. | |
dc.identifier.issn | 1353-8020 | es |
dc.identifier.issn | 1873-5126 | es |
dc.identifier.uri | https://hdl.handle.net/11441/127954 | |
dc.description.abstract | Introduction: We aimed to assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson’s disease (PD) without dementia.
Methods: The study included a total of 180 non-demented PD patients and 45 healthy controls, who underwent
structural MRI acquisitions and standardized neurocognitive assessment through the PD-Cognitive Rating Scale (PD-CRS) within the multicentric COPPADIS-2015 study. A subset of 73 patients also had Diffusion Tensor Imaging (DTI) acquisitions. Volumetric and microstructural (mean diffusivity, MD) indices of CBF degeneration were automatically extracted using a stereotactic CBF atlas. For comparison, we also assessed multimodal indices of hippocampal degeneration. Associations between imaging measures and cognitive performance were assessed using linear models.
Results: Compared to controls, CBF volume was not significantly reduced in PD patients as a group. However,
across PD patients lower CBF volume was significantly associated with lower global cognition (PD-CRStotal: r =0.37, p <0.001), and this association remained significant after controlling for several potential confounding variables (p =0.004). Analysis of individual item scores showed that this association spanned executive and memory domains. No analogue cognition associations were observed for CBF MD. In covariate-controlled models, hippocampal volume was not associated with cognition in PD, but there was a significant association for hippocampal MD (p =0.02). Conclusions: Early cognitive deficits in PD without dementia are more closely related to structural MRI measures of CBF degeneration than hippocampal degeneration. In our multicentric imaging acquisitions, DTI-based diffusion measures in the CBF were inferior to standard volumetric assessments for capturing cognition- relevant changes in non-demented PD. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Parkinsonism & Related Disorders, 88, 68-75. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Nucleus basalis Meynert | es |
dc.subject | Substantia innominata | es |
dc.subject | MRI | es |
dc.subject | DTI | es |
dc.subject | Diffusion | es |
dc.subject | Parkinson’s disease | es |
dc.title | In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Psicología Experimental | es |
dc.identifier.doi | org/10.1016/j.parkreldis.2021.05.027 | es |
dc.journaltitle | Parkinsonism & Related Disorders | es |
dc.publication.volumen | 88 | es |
dc.publication.initialPage | 68 | es |
dc.publication.endPage | 75 | es |