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Artículo
Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot
(MDPI, 2020)
Autophagy is a highly conserved degradation mechanism that is essential for maintaining cellular homeostasis. In human disease, autophagy pathways are frequently deregulated and there is immense interest in targeting ...
Artículo
Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer
(Elsevier, 2020-03-16)
Cancer cells have unlimited replicative potential, insensitivity to growth-inhibitory signals, evasion of apoptosis,cellular stress, and sustained angiogenesis, invasiveness and metastatic potential. Cancer cells adequately ...
Artículo
NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction
(Impact Journals, 2017)
The NLRP3-inflammasome complex has emerged as an important component of inflammatory processes in metabolic dysfunction induced by high-caloric diets. In this study, we investigate the molecular mechanisms by which NLRP3 ...
Artículo
Altered myogenesis and premature senescence underlie human TRIM32-related myopathy
(Springer Nature, 2019-03-01)
TRIM32 is a E3 ubiquitin -ligase containing RING, B-box, coiled-coil and six C-terminal NHL domains. Mutations involving NHL and coiled-coil domains result in a pure myopathy (LGMD2H/STM) while the only described mutation ...