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Artículo
Síntesis estereoselectiva de una nueva familia de beta -aminoésteres de interés farmacológico como inhibidores potenciales de la agregación plaquetaria.
(Universidad pablo de Olavide, 2015)
Motivación: La utilización de compuestos estereoquímicamente puros presenta numerosas ventajas frente al uso de racematos en la industria farmacéutica, debido principalmente a la estrecha e importante relación existente ...
Artículo
N -Isopropylsulfinylimines vs. N-tert -butylsulfinylimines in the stereoselective synthesis of sterically hindered amines: An improved synthesis of enantiopure (R)- And (S)-rimantadine and the trifluoromethylated analogues
(Royal Society of Chemistry, 2019-11-04)
An improved fully stereoselective synthesis of both enantiomers of rimantadine and its trifluoromethylated analogues has been developed, using N-isopropylsulfinylimines as a starting chiral material, proving the superiority ...
Artículo
Synthesis and characterization of enantiopure chiral NH2/SO palladium complexes
(Royal Society of Chemistry, 2023)
A series of enantiopure chiral NH2/SO palladium complexes have been synthesised with high yields by treating the corresponding tert-butylsulfinamide/sulfoxide derivatives with Pd(CH3CN)2Cl2. The enantiopure chiral ligands ...
Tesis Doctoral
Derivados quirales de azufre y de fósforo: síntesis y aplicaciones en catálisis asimétrica
(2014-12-19)
El trabajo presentado en esta Tesis Doctoral forma parte de un proyecto de investigación más amplio desarrollado a lo largo de los últimos años por nuestro grupo de investigación, que tiene por objeto la síntesis ...
Artículo
Proline-coated gold nanoparticles as a highly efficient nanocatalyst for the enantioselective direct aldol reaction in water
(Royal Society of Chemistry, 2013)
Reported is an efficient approach to the synthesis of water-soluble proline-coated gold nanoparticles through a place exchange reaction between pentanethiolate stabilized gold nanoparticles and a proline-tethered amphiphilic ...
Tesis Doctoral
Artículo
New sulfur-phosphine ligands derived from sugars: synthesis and application in palladium-catalyzed allylic alkylation and in rhodium asymmetric hydrogenation
(Arkat USA, 2008)
An efficient route to mixed phosphine / thioglycoside ligands type IV starting from glucose pentaacetate is reported. In only five steps the key epoxide 6 has been obtained in high yield and its structure determined by ...
Artículo
Tailoring carbon nanotube surfaces with glyconanorings: New bionanomaterials with specific lectin affinity
(Royal Society of Chemistry, 2009)
Remarkably stable, water-soluble glyconanoring-coated SWCNTs were prepared by self organization and photopolymerization of neutral diacetylene-based glycolipids on the nanotube surface; the nanoconstructs are able to engage ...
Ponencia
Design and synthesis of supramolecular hydrogels for biomedical applications
(Universidad Pablo de Olavide, 2016)
Motivation: Only a few cells in the human organism keep their ability to regenerate. Hence, modern medical research intends to develop new ways to cultivate these cells with high regenerative capacity with the aim to ...