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Mostrando ítems 1-6 de 6
Artículo
Impact of a Loss-of-Function Variant in HSD17B13 on Hepatic Decompensation and Mortality in Cirrhotic Patients
(MDPI AG, 2022)
Abstract: A common splice variant in HSD17B13 (rs72613567:TA) was recently found to be associated with a reduced risk of developing chronic liver disease in NAFLD patients and a reduced risk of progression to advanced ...
Artículo
Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles
(Willey, 2022)
Background and Aims We previously identified subsets of patients with NAFLD with different metabolic phenotypes. Here we align metabolomic signatures with cardiovascular disease (CVD) and genetic risk factors. Approach ...
Artículo
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
(OXFORD UNIV PRESS, 2022)
Metabolic associated fatty liver disease (MAFLD) is the most prevalent form of liver disease worldwide, accounting for a high liver-related mortality and morbidity with extensive multi organ involvement. This entity has ...
Artículo
Systematic review and meta-analysis: analysis of variables influencing the interpretation of clinical trial results in NAFLD
(SPRINGER, 2022)
Background NAFLD clinical trials have shown suboptimal results, particularly for liver fibrosis, despite the robust preclinical drug development. We aimed to assess the histological response after the experimental treatment ...
Artículo
Vitality, mental health and role-physical mediate the influence of coping on depressive symptoms and self-efficacy in patients with non-alcoholic fatty liver disease: a cross-sectional study
(Elsevier, 2022)
Objective: Our aim was to determine whether the association between active coping and depressive symptoms in patients with non-alcoholic fatty liver disease (NAFLD) was mediated by vitality, and whether diabetes and obesity ...
Artículo
Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function
(Elsevier, 2022)
Background & Aims: Autophagy-related gene 3 (ATG3) is an enzyme mainly known for its actions in the LC3 lipidation pro cess, which is essential for autophagy. Whether ATG3 plays a role in lipid metabolism or contributes ...