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Artículo
Mistranslation drives alterations in protein levels and the effects of a synonymous variant at the fibroblast growth factor 21 locus
(WILEY, 2021)
Fibroblast growth factor 21 (FGF21) is a liver-derived hormone with pleiotropic beneficial effects on metabolism. Paradoxically, FGF21 levels are elevated in metabolic diseases. Interventions that restore metabolic ...
Artículo
A variant in the MICA gene is associated with liver fbrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms
(Nature Research, 2019-02-05)
Hepatocarcinogenesis is tightly linked to liver fibrosis. Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma ...
Artículo
Copy number variation and expression of exportin-4 associates with severity of fibrosis in metabolic associated fatty liver disease
(Elsevier Science, 2021-08-11)
Background Liver fibrosis risk is a heritable trait, the outcome of which is the net deposition of extracellular matrix by hepatic stellate cell-derived myofibroblasts. Whereas nucleotide sequence variations have been ...