Now showing items 1-10 of 30
Modelling the epidemiology of Escherichia coli ST131 and the impact of interventions on the community and healthcare centres
(Cambridge University Press, 2016)
ST131 Escherichia coli is an emergent clonal group that has achieved successful worldwide spread through a combination of virulence and antimicrobial resistance. Our aim was to develop a mathematical model, based on ...
Temocillin versus meropenem for the targeted treatment of bacteraemia due to third-generation cephalosporin-resistant Enterobacterales (ASTARTÉ): protocol for a randomised, pragmatic trial
(BMJ Publishing Group, 2021)
Introduction: Alternatives to carbapenems are needed in the treatment of third-generation cephalosporin-resistant Enterobacterales (3GCR-E). Temocillin is a suitable candidate, but comparative randomised studies are lacking. ...
Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study
Background The clinical presentation of COVID-19 in patients admitted to hospital is heterogeneous. We aimed to determine whether clinical phenotypes of patients with COVID-19 can be derived from clinical data, to assess ...
Phenotypic and molecular characterizations of carbapenem-resistant Acinetobacter baumannii isolates collected within the EURECA study
(Elsevier Science, 2021)
Multi-drug-resistant Acinetobacter baumannii isolates are key pathogens that contribute to the global bur den of antimicrobial resistance. This study aimed to investigate the phenotypic and molecular character istics of ...
European 'NAFLD Preparedness Index' - Is Europe ready to meet the challenge of fatty liver disease?
(Elsevier BV, 2021)
Background & Aims: Non-alcoholic fatty liver disease (NAFLD), which is closely associated with obesity, metabolic syndrome, and diabetes, is a highly prevalent emerging condition that can be optimally managed through a ...
Impact of an antimicrobial stewardship program on the incidence of carbapenem resistant gram-negative bacilli: an interrupted time-series analysis
Carbapenem-resistant Gram-negative bacilli (CR-GNB) are a critical public health threat, and carbapenem use contributes to their spread. Antimicrobial stewardship programs (ASPs) have proven successful in reducing antimicrobial ...
Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study
(Public Library Science, 2022)
Background Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and ...
Assessing the impact of COVID-19 on liver cancer management (CERO-19)
(Elsevier BV, 2021)
Background & Aims: The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems and it may have heavily impacted patients with liver cancer (LC). Herein, we evaluated whether ...
Sofosbuvir improves HCV-induced insulin resistance by blocking IRS1 degradation
In the present study, we have demonstrated that sofos buvir (SOF) treatment improves systemic insulin resis tance in hepatitis C virus (HCV)-patients, and, for the first time, revealed which molecular mechanisms are ...