Now showing items 1-10 of 65
Metformin inhibits glutaminase activity and protects against hepatic encephalopathy
Aim: To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients. To analyze the impact of metformin on glutaminase activity and ...
Hepatitis C: crioglobulinemia y linfoma no-Hodgkin
La infección por el virus de la hepatitis C juega un papel principal en la patogénesis de la crioglobulinemia mixta, promoviendo la activación y expansión de las células B. Estos reajustes moleculares inducen la síntesis ...
Case Report: Acute-on-Chronic Liver Failure: Making the Diagnosis between Infection and Acute Alcoholic Hepatitis
(Thieme Medical Publishers, 2016-06)
Acute-on-chronic liver failure (ACLF) represents a reversible syndrome associated with high short-term mortality, characterized by acute decompensation in patients with chronic liver disease and extrahepatic organ failure. ...
Obesity dependent metabolic signatures associated with nonalcoholic fatty liver disease progression
Our understanding of the mechanisms by which nonalcoholic fatty liver disease (NAFLD) progresses from simple steatosis to steatohepatitis (NASH) is still very limited. Despite the growing number of studies linking the ...
Switching from reference infliximab to CT-P13 in patients with inflammatory bowel disease: 12 months results
(Lippincott Williams & Wilkins, 2017)
Background: Biological agents, such as infliximab, have transformed the outcomes of patients with immune-mediated inflammatory diseases. The advent of biosimilar treatment options such as CT-P13 promises to improve the ...
Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy
(Sociedad Española de Patología Digestiva, 2018-02-01)
Aim: to analyze the effect of metformin on ammonia production derived from glutamine metabolism in vitro and in vivo. Methods: twenty male Wistar rats were studied for 28 days after a porto-caval anastomosis (n = 16) or ...
A variant in the MICA gene is associated with liver fbrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms
(Nature Research, 2019-02-05)
Hepatocarcinogenesis is tightly linked to liver fibrosis. Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma ...
Effect of Quercetin on Hepatitis C Virus Life Cycle: From Viral to Host Targets
Quercetin is a natural flavonoid, which has been shown to have anti hepatitis C virus (HCV) properties. However, the exact mechanisms whereby quercetin impacts the HCV life cycle are not fully understood. We assessed the ...
Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy
Hepatitis C virus (HCV) infection has been related to increased risk of development of hepa tocellular carcinoma (HCC) while metformin (M) and statins treatment seemed to protect against HCC development. In this work, we ...