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Artículo
Orai2 Modulates Store-Operated Ca2+ Entry and Cell Cycle Progression in Breast Cancer Cells
(MDPI, 2021-12-27)
Breast cancer is a heterogeneous disease from the histological and molecular expression point of view, and this heterogeneity determines cancer aggressiveness. Store-operated Ca2+ entry (SOCE), a major mechanism for Ca2+ ...
Artículo
Editorial: Involvements of TRP channels, oxidative stress and apoptosis in neurodegenerative diseases
(Fontiers Media SA, 2021)
The oxygen free radicals generated during metabolism can cause cumulative oxidative damage to nucleic acids, lipids, and protein, resulting in structural degeneration, apoptosis, functional decline, and age-related ...
Artículo
Urocortin Role in Ischemia Cardioprotection and the Adverse Cardiac Remodeling
(MDPI, 2021-11-09)
Despite the considerable progress in strategies of myocardial protection, ischemic heart diseases (IHD) and consequent heart failure (HF) remain the main cause of mortality worldwide. Several procedures are used routinely ...
Artículo
SARAF and Orai1 contribute to endothelial cell activation and angiogenesis
(FRONTIERS MEDIA SA, 2021)
Angiogenesis is a multistep process that controls endothelial cells (ECs) functioning to form new blood vessels from preexisting vascular beds. This process is tightly regulated by pro-angiogenic factors, such as vascular ...
Artículo
SARAF and EFHB Modulate Store-Operated Ca2+ Entry and Are Required for Cell Proliferation, Migration and Viability in Breast Cancer Cells
(MDPI, 2021)
Breast cancer is among the most common malignancies in women. From the molecular point of view, breast cancer can be grouped into different categories, including the luminal (estrogen receptor positive (ER+)) and triple ...
Artículo
miR-30b-5p Downregulation as a predictive biomarker of coronary in-stent restenosis
(2021-03-30)
In-stent restenosis (ISR) is one of the main limitations of percutaneous coronary intervention (PCI) therapy with drug-eluting stents (DES) implantation. The aim of this study was to determine if circulating microRNAs ...
Artículo
Editorial: A Compendium of Recent Research on Stem Cell-Based Therapy for Covid-19
(Frontiers Media, 2021-12-14)
We have been dealing with an unprecedented global health crisis for nearly 2 years now. This started after an outbreak of atypical pneumonia of unknown etiology that was described in late December 2019 in China’s Wuhan ...
Artículo
Melatonin downregulates TRPC6, impairing store-operated calcium entry in triple negative breast cancer cells
(Amer Soc Biochemistry Molecular Biology Inc, 2021)
Melatonin has been reported to induce effective reduction in growth and development in a variety of tumors, including breast cancer. In triple-negative breast cancer (TNBC) cells, melatonin attenuates a variety of cancer ...
Artículo
Furin prodomain ppfurin enhances ca2+ entry through orai and trpc6 channels’ activation in breast cancer cells
(MDPI, 2021-04-01)
Furin, a proprotein convertase that belongs to a family of Ca2+-dependent serine peptidases, is involved in the maturation of a variety of proproteins, including growth factors, receptors and differentiation factors, ...
Artículo
Editorial: Molecular Components of Store-Operated Calcium Entry in Health and Disease
(Frontiers Media, 2021-10-05)
Store-Operated Calcium Entry (SOCE) is a ubiquitous Ca2+ influx mechanism first described in 1986 (Putney, 1986). This conserved mechanism results from the interaction between the tetraspanning ORAI1 channel located in ...