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Artículo
La plasticidad sináptica mediada por endocannabinoides y «trastornos por consumo de drogas»
(Elsevier, 2019)
Las drogas impactan en los circuitos de recompensa cerebrales y originan depen dencia y adicción, lo que se define actualmente como trastornos por consumo de drogas. Los mecanismos de plasticidad sináptica en dichos ...
Artículo
The systemic administration of oleoylethanolamide exerts neuroprotection of the nigrostriatal system in experimental Parkinsonism
(CINP, 2013)
Oleoylethanolamide (OEA) is an agonist of the peroxisome proliferator-activated receptor α (PPARα) and has been described to exhibit neuroprotective properties when administered locally in animal models of several neurological ...
Artículo
Psychostimulant drugs and neuroplasticity
(MDPI AC, 2011-06-30)
Drugs of abuse induce plastic changes in the brain that seem to underlie addictive phenomena. These plastic changes can be structural (morphological) or synaptic (biochemical), and most of them take place in the mesolimbic ...
Artículo
Agregación de alfa-sinucleína y degeneración Parkinsoniana
(Sociedad Española de Ciencias Fisiológicas, 2013)
La alfa-sinucleína es la proteína principal de los cuerpos de Lewy, marcador anatomopatológico de la enfermedad de Parkinson. Dicha proteína puede ver alterada su conformación y adquirir capacidad autoagregante, lo que ...
Artículo
Serum protein halogenation and nitrosylation: trait of maintained overstimulation of blood phagocytes in sporadic Parkinson’s disease
(2013)
Introduction: Halogenative and nitrosative stress are two types of oxidative stress that have been proposed as pathogenic mechanisms in Parkinson’s disease (PD). They can be caused by overstimulation of phagocytes. This ...
Artículo
May the evaluation of nitrosative stress through selective increase of 3-nitrotyrosine proteins other than nitroalbumin and dominant tyrosine-125/136 nitrosylation of serum α-synuclein serve for diagnosis of sporadic Parkinson's disease?
(Mary Ann Liebert, Inc. Publishers, 2013)
Nitrosative stress, where nitrosylation of tyrosine (Tyr) leading to 3-nitrotyrosine proteins or free 3-nitrotyrosine is the most prominent change, has been proposed as a pathogenic mechanism in Parkinson's disease (PD). ...
Artículo
Líneas maestras del futuro de la investigación en trastornos adictivos
(Farmaindustria, 2010)