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Tesis Doctoral
Caracterización de MYBBP como un nuevo gen supresor de tumores
(2017-06-26)
El microambiente tumoral es un entorno heterogéneo y dinámico que se caracteriza por las constantes interacciones entre las células tumorales y las células del estroma y los continuos cambios en la distribución de nutrientes ...
Tesis Doctoral
Estudio de la familia de proteínas Rho GTPasas en la biología del neuroblastoma
(2022-07-14)
El neuroblastoma (NB) es el tumor extracraneal sólido de aparición más común durante la edad pediátrica. El NB surge a raíz de un desarrollo erróneo del linaje simpatoadrenal de la cresta neural. Es una enfermedad muy ...
Capítulo de Libro
A pathophysiological view of the neural stem cell niche
(Nova Science Publishers, INC. U.S., 2011)
Neural stem cells were described in the nervous system some decades ago as being responsible for adult neurogenesis and hence the structural plasticity in the tissue. These cells reside in specialized niches where they are ...
Artículo
Transcriptomic and connectomic correlates of differential spatial patterning among gliomas
(Oxford University Press, 2022-10-18)
Unravelling the complex events driving grade-specific spatial distribution of brain tumour occurrence requires rich datasets from both healthy individuals and patients. Here, we combined open-access data from The Cancer ...
Artículo
Mast Cell Changes the Phenotype of Microglia via Histamine and ATP
(KARGER, 2021)
Background/Aims: Microglia are the dynamic motile phagocytes of the brain considered the first line of defense against threats or disturbances to the Central Nervous System (CNS). Microglia help orchestrate the immunological ...
Artículo
Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity
(Wiley Open Access, 2020)
Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse disease ...
Artículo
Podoplanin Gene Disruption in Mice Promotes in vivo Neural Progenitor Cells Proliferation, Selectively Impairs Dentate Gyrus Synaptic Depression and Induces Anxiety-Like Behaviors.
(2020-01-15)
Podoplanin (Pdpn), a brain-tumor-related glycoprotein identified in humans and animals, is endogenously expressed in several organs critical for life support such as kidney, lung, heart and brain. In the brain, Pdpn has ...
Artículo
Eficacia antiparkinsoniana de trasplantes de paraganglio carotídeo y aórtico abdominal
(Organització catalana de trasplantaments. Servei català de la salut societat catalana de trasplantament, 2000)
Tesis Doctoral
Tesis Doctoral