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Mostrando ítems 21-30 de 524
Artículo
Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival
(Dove Medical Press Ltd., 2015)
Chronic hypoxemia, as evidenced in de-acclimatized high-altitude residents or in patients with chronic obstructive respiratory disorders, is a common medical condition that can produce serious neurological alterations. ...
Tesis Doctoral
Estudios de efectos neurobiológicos del Δ9-tetrahidrocannabinol (THC) en modelos animales
(2012-06-15)
El sistema cannabinoide endógeno es un importante sistema de modulación de múltiples respuestas fisiológicas tanto a nivel central como periférico, constituido por una serie de receptores cannabinoides, ligandos endógenos ...
Artículo
Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy
(2018-01-31)
Hepatitis C virus (HCV) infection has been related to increased risk of development of hepa tocellular carcinoma (HCC) while metformin (M) and statins treatment seemed to protect against HCC development. In this work, we ...
Artículo
Orai2 Modulates Store-Operated Ca2+ Entry and Cell Cycle Progression in Breast Cancer Cells
(MDPI, 2021-12-27)
Breast cancer is a heterogeneous disease from the histological and molecular expression point of view, and this heterogeneity determines cancer aggressiveness. Store-operated Ca2+ entry (SOCE), a major mechanism for Ca2+ ...
Artículo
Altered Intracellular Ca2+ Homeostasis in Nerve Terminals of Severe Spinal Muscular Atrophy Mice
(SOC NEUROSCIENCE, 2010)
Low levels of survival motor neuron (SMN) protein result in spinal muscular atrophy (SMA), a severe genetic disease characterized by motor impairment and premature lethality. Although SMN is a ubiquitous protein, motor ...
Artículo
Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1 alpha
(NATURE PUBLISHING GROUP, 2014-04-04)
The neuromuscular junction (NMJ) exhibits high morphological and functional plasticity. In the mature muscle, the relative levels of physical activity are the major determinants of NMJ function. Classically, motor ...
Artículo
¿Cómo funciona el nucleus accumbens?
(2000)
El nucleus accumbens se considera una interfase neural entre motivación y acción motora, y participa de modo decisivo en la ingesta, conducta sexual, recompensa, respuesta al estrés, autoadminstración de drogas, etc. ...
Artículo
Artículo
Store-operated calcium entry in breast cancer cells is insensitive to Orai1 and STIM1 N-linked glycosylation
(MDPI, 2022-12-29)
N-linked glycosylation is a post-translational modification that affects protein function, structure, and interaction with other proteins. The store-operated Ca2+ entry (SOCE) core proteins, Orai1 and STIM1, exhibit ...
Tesis Doctoral