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Mostrando ítems 1-10 de 34
Artículo
Effect of hypoxia on lung gene expression and proteomic profile: insights into the pulmonary surfactant response
(Elsevier, 2014)
Exposure of lung to hypoxia has been previously reported to be associated with significant alterations in the protein content of bronchoalveolar lavage (BAL) and lung tissue. In the present work we have used a proteomic ...
Artículo
Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival
(Dove Medical Press Ltd., 2015)
Chronic hypoxemia, as evidenced in de-acclimatized high-altitude residents or in patients with chronic obstructive respiratory disorders, is a common medical condition that can produce serious neurological alterations. ...
Artículo
HIF-2a is essential for carotid body development and function
(eLife Sciences Publications, 2018-04-19)
Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations facilitated by the sympathetic nervous system and carotid body (CB). Interactions between differing ...
Patente. Invención
Composiciones capaces de modular la estimulación de GDNF endógeno para el tratamiento de enfermedades neurodegenerativas
(Organización Mundial de la Propiedad Intelectual (OMPI), 2019-03-07)
Compuestos y composiciones capaces de modular la estimulación de GDNF endógeno mediante la activación de los genes GPR83, KIT, TACRl, TACR3, MC3R, RARRES2, CRABPl, MOXDl, SPATA18 y/o LHX8 o las proteínas que codifican, ...
Artículo
Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion
(2016-12)
Biotin is a water-soluble vitamin required for the function of carboxylases as well asfor the regulation of gene expression. Here, we report that biotin accumulates in unusually largeamounts in cells of arterial chemoreceptors, ...
Artículo
The carotid body, a neurogenic niche in the adult peripheral nervous system
(Univ pisa, 2010)
We have described a new population of adult neural stem cells residing in the carotid body, a chemoreceptor organ in the peripheral nervous system. These progenitor cells support neurogenesis in vivo in response to ...
Capítulo de Libro
Clinical applications of cell therapy
(Edikamed, 2010)
Tesis Doctoral
Hipertrofia del cuerpo carotídeo en hipoxia crónica: mecanismos de activación, proliferación y diferenciación de los progenitores neurales en el sistema nervioso periférico
(2014-04-25)
The goal of this doctoral thesis is to achieve a better understanding of the biology and behavior of the recently discovered adult carotid body neural stem cells. The work focuses on two main objectives. First, to study ...
Artículo
Age-mediated transcriptomic changes in adult mouse substantia nigra
(2013)
Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson’s disease (PD). Until now, molecular mechanisms behind SNpc aging have not been fully investigated using ...