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Artículo
Identification and Functional Characterization of a K1 Channel a- Subunit with Regulatory Properties Specific to Brain
(1997)
The physiological diversity of K1 channels mainly depends on the expression of several genes encoding different a-subunits. We have cloned a new K1 channel a-subunit (Kv2.3r) that is unable to form functional channels on ...
Artículo
Artículo
Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells
(1994)
We have investigated the changes of cytosolic [Ca2+1 and the secretory -activity in single glomus cells dispersed from rabbit carotid bodies during exposure to solutions with variable 02 tension (Po2). In normoxic conditions ...
Artículo
Oxygen sensing by ion channels and chemotransduction in single glomus cells
(1996)
We have monitored cytosolic [Ca2+] and dopamine release in intact fura-2-loaded glomus cells with microfluoroimetry and a polarized carbon fiber electrode. Exposure to low PO2 produced a rise of cytosolic [Ca2+] with two ...
Artículo
Gating of O2-sensitive K + Channels of Arterial Chemoreceptor Cells and Kinetic Modifications Induced by Low PO2
(1992)
We have studied the kinetic properties of the O2-sensitive K+ channels (KO2 channels) of dissociated glomus cells from rabbit carotid bodies exposed to variable O2 tension (PO2). Experiments were done using single-channel ...
Artículo
Thyrotropin-releasing-hormone (TRH) and its physiological metabolite TRH-OH inhibit Na+ channel activity in mammalian septal neurons
(1990)
The interaction of thyrotropin-releasing hormone (TRH) and its physiological metabolite TRH-OH with Na+ channels was studied in enzymatically dissociated guinea pig septal neurons by using the whole-cell variant of the ...
Artículo
Single K+ channels in membrane patches of arterial chemoreceptor cells are modulated by 02 tension
(1991)
Type I cells of the carotid body are known to participate in the detection of 02 tension in arterial blood but the primary chemotransduction mechanisms are not well understood. Here we report the existence in excised ...
Tesis Doctoral
Canales de calcio de las células glómicas y su modulación por dopamina
(1991-07-16)
El presente trabajo se centra en el estudio de los canales de Ca2+ de alto umbral y de su modulación metabólica y por neurotransmisores. Los experimentos se han realizado en células quimiosensoras del cuerpo carotídeo ...
Tesis Doctoral
Patente. Invención
Utilización en composiciones farmacológicas de agentes con efecto reductor o inductor de hipoxia
(Oficina Española de Patentes y Marcas (OEPM), 1999-07-01)
Utilización en composiciones farmacológicas de agentes con efecto reductor o inductor de hipoxia. Se propone como nueva la utilización en preparados farmacológicos de agentes reductores, y en general aquellos que produzcan ...