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Artículo
Differential impairment of catecholaminergic cell maturation and survival by genetic mitochondrial complex II dysfunction
(2012)
The SDHD gene (subunit D of succinate dehydrogenase) has been shown to be involved in the generation of paragangliomas and pheochromocytomas. Loss of heterozygosity of the normal allele is necessary for tumor transformation ...
Tesis Doctoral
Mecanismos Moleculares de Formación de Tumores en Modelos Genéticos Animales con Defectos Mitocondriales por Deleción del Gen SdhD
(2015)
La disfunción mitocondrial está ampliamente vinculada con la tumorogénesis. Una de las características principales de las células cancerosas es el cambio desde un metabolismo oxidativo mitocondrial dependiente de oxígeno ...
Ponencia
Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells
(John Wiley & Sons, 2006)
Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from inhibition of O2-regulated K+ channels. The mechanisms involved in the detection of changes of O2 ...
Tesis Doctoral
Generación y análisis del ratón mutante condicional en la subunidad D del complejo II mitocondrial: efecto sobre el sistema nervioso central y el periférico
(2012)
SDHD es un gen supresor de tumores en humanos. Este gen codifica para una (SDHD) de las cuatro proteínas que forman parte el complejo II mitocondrial de la cadena de transporte de electrones. Los individuos que portan ...
Artículo
An O-2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hipoxia
(CELL PRESS, 2014-01-16)
Neural stem cells (NSCs) exist in germinal centers of the adult brain and in the carotid body (CB), an oxygen-sensing organ that grows under chronic hypoxemia. How stem cell lineage differentiation into mature glomus cells ...
Artículo
The Mitochondrial SDHD Gene Is Required for Early Embryogenesis, and Its Partial Deficiency Results in Persistent Carotid Body Glomus Cell Activation with Full Responsiveness to Hypoxia
(2004)
The SDHD gene encodes one of the two membrane-anchoring proteins of the succinate dehydrogenase (complex II) of the mitochondrial electron transport chain. This gene has recently been proposed to be involved in oxygen ...