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Mostrando ítems 1-10 de 43
Artículo
Preparation, characterization and evaluation of the anti-inflammatory activity of epichlorohydrin-β-cyclodextrin/curcumin binary systems embedded in a pluronic® /hyaluronate hydrogel
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Curcumin (Cur) is an anti-inflammatory polyphenol that can be complexed with polymeric cyclodextrin (CD) to improve solubility and bioavailability. The aim of the present work was to prepare a CurCD hydrogel to treat ...
Artículo
Evaluation of poly (lactic-co-glycolic acid) nanoparticles to improve the therapeutic efficacy of paclitaxel in breast cancer
(Universidad de Ciencias Médicas de Tabriz, 2022)
Introduction: Paclitaxel (PTX) is a cornerstone in the treatment of breast cancer, the most common type of cancer in women. However, this drug has serious limitations, including lack of tissue-specificity, poor water ...
Artículo
El mortero emigrante. Crónica de los primeros boticarios españoles que pasaron a Indias
(Departamento de Historia de América, Universidad de Sevilla, 2022)
El descubrimiento del Nuevo Mundo supuso un intercambio de personas y mercaderías que se materializaría en fuertes ingresos para la Corona Española desde comienzos del siglo XVI. Los boticarios participaron de estas ...
Artículo
Assessment of the Extrusion Process and Printability of Suspension-Type Drug-Loaded AffinisolTM Filaments for 3D Printing
(MDPI, 2022)
Three-dimensional (3D) printing technology enables the design of new drug delivery systems for personalised medicine. Polymers that can be molten are needed to obtain extruded filaments for Fused Deposition Modelling (FDM), ...
Artículo
Receptor-targeted nanoparticles modulate cannabinoid anticancer activity through delayed cell internalization
(Nature Research, 2022)
Δ9-tetrahydrocannabinol (Δ9-THC) is known for its antitumor activity and palliative effects. However, its unfavorable physicochemical and biopharmaceutical properties, including low bioavailability, psychotropic side effects ...
Artículo
Brain Organoids to Evaluate Cellular Therapies
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Animal models currently used to test the efficacy and safety of cell therapies, mainly murine models, have limitations as molecular, cellular, and physiological mechanisms are often inherently different between species, ...
Artículo
Biologically Relevant Micellar Nanocarrier Systems for Drug Encapsulation and Functionalization of Metallic Nanoparticles
(MDPI, 2022)
The preparation of new and functional nanostructures has received more attention in the scientific community in the past decade due to their wide application versatility. Among these nanostructures, micelles appear to be ...
Capítulo de Libro
Contribuciones alfonsíes en ciencias de la salud: la disyuntiva entre ciencia y magia
(Editorial Universidad de Sevilla, 2022)
Artículo
Synergistic effect of acetazolamide-(2-hydroxy)propyl β-cyclodextrin in timolol liposomes for decreasing and prolonging intraocular pressure levels
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
The purpose of this study was to design, for the first time, a co-loaded liposomal formulation (CLL) for treatment of glaucoma including timolol maleate (TM) in the lipid bilayer and acetazolamide (Acz)-(2-hydroxy)propyl ...
Artículo
Cholesterol levels affect the performance of aunps-decorated thermo-sensitive liposomes as nanocarriers for controlled doxorubicin delivery
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Stimulus-responsive liposomes (L) for triggering drug release to the target site are particularly useful in cancer therapy. This research was focused on the evaluation of the effects of cholesterol levels in the performance ...