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Artículo
Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot
(MDPI, 2020)
Autophagy is a highly conserved degradation mechanism that is essential for maintaining cellular homeostasis. In human disease, autophagy pathways are frequently deregulated and there is immense interest in targeting ...
Artículo
Update on the treatment of metastatic renal cell carcinoma
(BAISHIDENG PUBLISHING GROUP INC, 2022)
Metastatic renal cell cancer (mRCC) management has undergone a paradigm shift in recent decades. The first revolution came with the emergence of vascular endothelial growth factor inhibitors; there was a second wave with ...
Artículo
Dasatinib, a Src inhibitor, sensitizes liver metastatic colorectal carcinoma to oxaliplatin in tumors with high levels of phospho-Src.
(Impact Journals, 2016-04-20)
Despite the development of new antineoplastic agents for the treatment of colorectal cancer (CRC), oxaliplatin and fluoropyrimidines remain the most commonly employed drugs for the treatment of both early and advanced ...