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Mostrando ítems 11-20 de 37
Artículo
Proteostasis Dysfunction in Aged Mammalian Cells. The Stressful Role of Inflammation
(Frontiers Media S.A., 2021)
Aging is a biological and multifactorial process characterized by a progressive and irreversible deterioration of the physiological functions leading to a progressive increase in morbidity. In the next decades, the world ...
Artículo
Effect of Age and Lipoperoxidation in Rat and Human Adipose Tissue-Derived Stem Cells
(Hindawi, 2020)
A wide range of clinical applications in regenerative medicine were opened decades ago with the discovery of adult stem cells. Highly promising adult stem cells are mesenchymal stem/stromal cells derived from adipose tissue ...
Artículo
HERC1 Ubiquitin Ligase Is Required for Hippocampal Learning and Memory
(Frontiers Media, 2020)
Mutations in the human HERC1 E3 ubiquitin ligase protein develop intellectual disability. The tambaleante (tbl) mouse carries a HERC1 mutation characterized by cerebellar ataxia due of adult cerebellar Purkinje cells death ...
Artículo
Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1
(Springer, 2021)
Genetic Alzheimer’s disease (AD) risk factors associate with reduced defensive amyloid β plaque-associated microglia (AβAM), but the contribution of modifiable AD risk factors to microglial dysfunction is unknown. In AD ...
Artículo
The Other Side of SARS-CoV-2 Infection: Neurological Sequelae in Patients
(Frontiers Media S.A., 2021)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the globe causing coronavirus disease 2019 (COVID-19). Because it affects the respiratory system, common symptoms are cough and breathing ...
Artículo
Conversion of Whey into Value-Added Products through Fermentation and Membrane Fractionation
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
The cheese whey (95% composed of water) is an effluent produced in the cheese industry, of which more than 1.5 million tons are generated in Spain, constituting a serious environmental problem. The process starts with a ...
Artículo
Microglia: Agents of the CNS Pro-Inflammatory Response
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
The pro-inflammatory immune response driven by microglia is a key contributor to the pathogenesis of several neurodegenerative diseases. Though the research of microglia spans over a century, the last two decades have ...
Artículo
The HERC proteins and the nervous system
(Elsevier, 2021)
The HERC protein family is one of three subfamilies of Homologous to E6AP C-terminus (HECT) E3 ubiquitin ligases. Six HERC genes have been described in humans, two of which encode Large HERC proteins -HERC1 and HERC2- with ...
Artículo
Amyloid-β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease
(Wiley, 2020)
Reactive astrocytes and dystrophic neurites, most aberrant presynaptic elements, are found surrounding amyloid-β plaques in Alzheimer's disease (AD). We have previously shown that reactive astrocytes enwrap, phagocytose, ...
Artículo
Nutritional quality of the most consumed varieties of raw and cooked rice in Spain submitted to an in vitro digestion model
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Rice is one of the most consumed staple foods around the world and its trade is highly globalized. Increased environmental pollution generates a large amount of waste that, in many cases, is discarded close to culture ...