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Mostrando ítems 1-10 de 20
Artículo
Brainiac Caspases: Beyond the Wall of Apoptosis
(Frontiers Media, 2019)
For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions. In this mini review, ...
Artículo
Docosahexaenoic acid reduces microglia phagocytic activity via miR-124 and induces neuroprotection in rodent models of spinal cord contusion injury
(Oxford University Press, 2019-07-15)
Microglia are activated after spinal cord injury (SCI), but their phagocytic mechanisms and link to neuroprotection remain incompletely characterized. Docosahexaenoic acid (DHA) has been shown to have significant neuroprotective ...
Artículo
Microglia: Agents of the CNS Pro-Inflammatory Response
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
The pro-inflammatory immune response driven by microglia is a key contributor to the pathogenesis of several neurodegenerative diseases. Though the research of microglia spans over a century, the last two decades have ...
Artículo
The role of Galectin-3 in α-synuclein-induced microglial activation
(BioMed Central, 2014)
Background: Parkinson ’ s disease (PD) is the most prevalent neurodegenerative motor disorder. The neuropathology is characterized by intraneuronal protein aggregates of α -synuclein and progressive degeneration of ...
Artículo
Reformulating Pro-Oxidant Microglia in Neurodegeneration
(MDPI, 2019)
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered ...
Artículo
TET2 Regulates the Neuroinflammatory Response in Microglia
(Elsevier, 2019)
Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for microglia in neuroinflammation and neurodegeneration, little is known about their epigenomic ...
Artículo
Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype
(Springer Nature, 2016-10-19)
Glioma cells recruit and exploit microglia (the resident immune cells of the brain) for their proliferation and invasion ability. The underlying molecular mechanism used by glioma cells to transform microglia into a ...
Artículo
Microglia-secreted galectin-3 acts as a toll-like receptor 4 ligand and contributes to microglial activation
(2015)
Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia’s inflammatory response ...
Artículo
Cell Death Related Proteins Beyond Apoptosis in the CNS
(Frontiers Media S.A., 2022)
Cell death related (CDR) proteins are a diverse group of proteins whose original function was ascribed to apoptotic cell death signaling. Recently, descriptions of non-apoptotic functions for CDR proteins have increased. ...
Artículo
Caspase signalling controls microglia activation and neurotoxicity
(Springer Nature, 2011-04-11)
Activation of microglia and inflammation-mediated neurotoxicity are suggested to play a decisive role in the pathogenesis of several neurodegenerative disorders. Activated microglia release pro-inflammatory factors that ...