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Artículo
Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease
(Nature Research (part of Springer Nature), 2017)
Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. Over the past two decades, multiple studies have focused on elucidating the causative factors ...
Artículo
Genetic Rescue of Mitochondrial and Skeletal Muscle Impairment in an Induced Pluripotent Stem Cells Model of Coenzyme Q10 Deficiency
(Wiley-Blackwell, 2017-07)
Coenzyme Q10 (CoQ10) plays a crucial role in mitochondria as an electron carrier within the mitochondrial respiratory chain (MRC) and is an essential antioxidant. Mutations in genes responsible for CoQ10 biosynthesis (COQ ...
Artículo
Sanitary impact evaluation of drinking water in storage reservoirs in Moroccan rural area
(King Saud University, 2017)
In Morocco, storage reservoirs are particular systems of water supply in rural areas. These reservoirs are fed with rainwater and/or directly from the river, which are very contaminated by several pathogenic bacteria. They ...
Artículo
Neuroinflammation alters cellular proteostasis by producing endoplasmic reticulum stress, autophagy activation and disrupting ERAD activation
(Nature Publishing Group, 2017)
Proteostasis alteration and neuroinflammation are typical features of normal aging. We have previously shown that neuroinflammation alters cellular proteostasis through immunoproteasome induction, leading to a transient ...
Artículo
Insecticide Reproductive Toxicity Profile: Organophosphate, Carbamate and Pyrethroids
(Avens Publishing Group, 2017)
Exposure to pesticides is very common world-wide, and is broadly known the acute toxic effects to humans of pesticides following a high dose exposure; however, knowledge about chronic low-dose adverse effects to specific ...
Artículo
Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration
(Nature, 2017)
Traumatic brain injury (TBI) is currently a major cause of morbidity and poor quality of life in Western society, with an estimate of 2.5 million people affected per year in Europe, indicating the need for advances in TBI ...
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Effect of VBC-1814/7J, a poly-phytocompound, on a non-infectious model of pharyngitis
(Spandidos Publications, 2017)
Pharyngitis presents as an inflammation of the oropharynx, and clinical examination often shows evidence of nasopharyngitis. In numerous cases the condition occurs as a self-limiting illness of non-infectious aetiology, ...
Artículo
Impact of fertilization by natural manure on the microbial quality of soil: Molecular approach
(King Saud University, 2017)
The quality of soil is strongly bound by several interactions between chemical and biological components, including microbial composition, which are a key importance for soil performance. Cultural activities have a huge ...
Artículo
Photosynthetic activity of cotyledons is critical during post-germinative growth and seedling establishment
(Taylor & Francis, 2017)
Thioredoxins (Trxs) play a relevant role in thiol-dependent redox regulation, which allows the rapid adaptation of chloroplast metabolism to unpredictable environmental conditions. In chloroplasts, Trxs use reducing ...
Artículo
Immunolocalization of Substance P and NK-1 Receptor in ADIPOSE Stem Cells
(Wiley-Blackwell, 2017)
Substance P (SP) is a neuropeptide belonging to the thachykinin peptide family. SP, after binding to its receptor, the neurokinin 1 receptor (NK1R), controls several transcription factors such as NF-κB, hypoxia inducible ...