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Mostrando ítems 1-9 de 9
Artículo
Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour
(Elsevier, 2021-01-10)
Apoptotic caspases are thought to play critical roles in elimination of excessive and non-functional synapses and removal of extra cells during early developmental stages. Hence, an impairment of this process may thus ...
Artículo
Inflammatory bowel disease induces pathologicalα-synucleinaggregation in the human gut and brain
(Wiley, 2024-01-16)
Aims According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether ...
Artículo
Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease
(Frontiers Media, 2018)
The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the ...
Artículo
Relevance of chronic stress and the two faces of microglia in Parkinson’s disease
(rontiers Research Foundation, 2015)
This review is aimed to highlight the importance of stress and glucocorticoids (GCs) in modulating the inflammatory response of brain microglia and hence its potential involvement in Parkinson’s ...
Artículo
Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
(Springer Nature, 2022)
The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are inherently associated with disease conditions. A common feature of some of these activated phenotypes ...
Artículo
Inflammatory Animal Models of Parkinson's Disease
(IOS Press, 2022)
Accumulating evidence suggests that microglia and peripheral immune cells may play determinant roles in the pathogenesis of Parkinson's disease (PD). Consequently, there is a need to take advantage of immune-related models ...
Artículo
The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior
(Frontiers Media S.A., 2022)
In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an important role in the sculpting of the brain in the early stages of development by eliminating excessive ...
Artículo
Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon
(Frontiers Media, 2021)
Parkinson’s disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the knowledge of risk factors as well as the development of new putative molecular targets is mandatory. In ...
Artículo
Reformulating Pro-Oxidant Microglia in Neurodegeneration
(MDPI, 2019)
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered ...