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Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease [Article]
(Frontiers Media, 2018)
The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues as cortical neurons, for example. However, the effect of metformin ...
Relevance of chronic stress and the two faces of microglia in Parkinson’s disease [Article]
(rontiers Research Foundation, 2015)
This review is aimed to highlight the importance of stress and glucocorticoids (GCs) in modulating the inflammatory response of brain microglia and hence its potential involvement in Parkinson’s ...
TET2 Regulates the Neuroinflammatory Response in Microglia [Article]
Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for microglia in neuroinflammation and neurodegeneration, little is known about their epigenomic ...