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AuthorVitorica Ferrández, Francisco Javier (13)Sánchez Varo, Raquel María (9)Vizuete Chacón, María Luisa (9)Sánchez Mejías, Elisabeth (8)Gutiérrez Pérez, Antonia (6)Jiménez Muñoz, Sebastián (6)Navarro Garrido, Victoria (6)Gómez Arboledas, Ángela (5)Baglietto Vargas, David (4)Dávila Cansino, José Carlos (4)... View MoreSubjectAlzheimer’s disease (4)Microglia (3)Alzheimer (2)Amyloid (2)Astrocytes (2)Electron microscopy (2)Neurodegeneration (2)Oligodendrocytes (2)Transgenic mice (2)3D cultures (1)... View MoreDate Issued2020 - 2022 (10)2011 - 2019 (7)Funding agency
Instituto de Salud Carlos III (17)
Junta de Andalucía (13)European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) (7)Universidad de Málaga (6)Ministerio de Economía y Competitividad (MINECO). España (5)Ministerio de Ciencia e Innovación (MICIN). España (3)Ministerio de Educación, Cultura y Deporte (MECD). España (2)Alzheimer Association (1)Centro de Invesitgacion Biomedica en Red Enfermedades Neurodegenetativas. (CIBERNED) España (1)Centro de Investigaciones Biomédicas en Red (CIBERNED) (1)... View More
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Article
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Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density 

Pintado Losa, Cristina; Revilla Torres, María Elisa; Vizuete Chacón, María Luisa; García Cuervo, Luisa; Vitorica Ferrández, Francisco Javier; Ruano Caballero, Diego; Castaño Navarro, Angélica (Elsevier, 2011)
To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays using three different densities of N13 microglia stimulated with LPS. Our results showed that ...
Article
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Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells 

García Bonilla, María; García-Martín, María Luisa; Ojeda Pérez, Betsaida; Muñoz Hernández, Mª Carmen; Vitorica Ferrández, Francisco Javier; Jiménez Muñoz, Sebastián; Cifuentes, Manuel; Santos Ruíz, Leonor; Shumilov, Kirill; Claros, Silvia; Páez González, Patricia; Jiménez, Antonio J. (BMC, 2020)
BACKGROUND: In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, ...
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White Button Mushroom Extracts Modulate Hepatic Fibrosis Progression, Inflammation, and Oxidative Stress In Vitro and in LDLR-/- Mice 

Gallego Yerga, Paloma; Luque Sierra, Amparo; Falcón García, Gonzalo; Carbonero Aguilar, María del Pilar; Grande Santamaría, Lourdes; Bautista Palomas, Juan Dionisio; Martín, Franz (MDPI, 2021)
Liver fibrosis can be caused by non-alcoholic steatohepatitis (NASH), among other conditions. We performed a study to analyze the effects of a nontoxic, water-soluble extract of the edible mushroom Agaricus bisporus (AB) ...
Article
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Human Pluripotent Stem Cell-Derived Neural Cellsas a Relevant Platform for Drug Screening inAlzheimer’s Disease 

García León, Juan Antonio; Cáceres Palomo, Laura; Sánchez Mejías, Elisabeth; Mejías Ortega, Marina; Núñez Díaz, Cristina; Fernández Valenzuela, Juan José; Sánchez Varo, Raquel María; Dávila Cansino, José Carlos; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (MDPI, 2020)
Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tanglesare prime features of Alzheimer’s disease (AD). The pathology of AD is very complex and still notfully understood, since different ...
Article
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AICAR Stimulates the Pluripotency Transcriptional Complex in Embryonic Stem Cells Mediated by PI3K, GSK3β, and β-Catenin 

Alba Jiménez, Gonzalo; Martínez, Raquel; Postigo Corrales, Fátima; López Enríquez, Soledad; Santa-María Pérez, Consuelo; Jiménez Carrasco, Juan; Cahuana Macedo, Gladys Margot; Soria Escoms, Bernat; Bedoya Bergua, Francisco Javier; Tejedo Huamán, Juan Rigoberto (American Chemical Society, 2020)
Pluripotent stem cells maintain the property of self-renewal and differentiate into all cell types under clear environments. Though the gene regulatory mechanism for pluripotency has been investigated in recent years, it ...
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In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology 

Trujillo Estrada, Laura Isabel; Jiménez Muñoz, Sebastián; Castro, Vanessa de; Torres Canalejo, Manuel; Baglietto Vargas, David; Moreno González, Inés; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier (BioMed Central, 2013)
Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies, ...
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Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients 

Sánchez Mejías, Elisabeth; Núñez Díaz, Cristina; Sánchez Varo, Raquel María; Gómez Arboledas, Ángela; García León, Juan Antonio; Fernández Valenzuela, Juan José; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Wiley Open Access, 2019)
Neuronal loss is the best neuropathological substrate that correlates with cortical atrophy and dementia in Alzheimer’s disease (AD). Defective GABAergic neuronal functions may lead to cortical network hyperactivity and ...
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Amyloid-β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease 

Sánchez Mico, María; Jiménez Muñoz, Sebastián; Gómez Arboledas, Ángela; Muñoz Castro, Clara; Romero Molina, Carmen; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier (Wiley, 2020)
Reactive astrocytes and dystrophic neurites, most aberrant presynaptic elements, are found surrounding amyloid-β plaques in Alzheimer's disease (AD). We have previously shown that reactive astrocytes enwrap, phagocytose, ...
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Galectin‑3, a novel endogenous TREM2 ligand, detrimentally regulates infammatory response in Alzheimer’s disease 

Boza Serrano, Antonio; Ruíz Laza, Rocio; Sánchez Varo, Raquel María; García Revilla, Juan; Yang, Yiyi; Jiménez Ferrer, Itzia; Jiménez Muñoz, Sebastián; Roca Ceballos, María Angustias; Navarro Garrido, Victoria; Vitorica Ferrández, Francisco Javier; Venero Recio, José Luis; Deierborg, Tomas (Springer, 2019)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are ...
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Phages in Food Industry Biocontrol and Bioremediation 

Cristobal Cueto, Pablo; García Quintanilla, Alberto; Esteban, Jaime; García Quintanilla, Meritxell de Jesús (MDPI, 2021)
Bacteriophages are ubiquitous in nature and their use is a current promising alternative in biological control. Multidrug resistant (MDR) bacterial strains are present in the livestock industry and phages are attractive ...
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