Browsing Artículos (Bioquímica y Biología Molecular) by Issue Date
Now showing items 21-40 of 77
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Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus [Article]
(2012)Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in Alzheimer’s patients and transgenic models at early ages. These axonal dystrophies ...
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Potential use of adipose tissue stem cells in the control of aging [Article]
(Federation of Anti-Aging Medicine Societies, 2012)Cell therapy with adult stem cells is a new battle front for the control of aging. Before being used for this purpose, we need to answer several basic questions about the biochemistry and physiology of these cells. This ...
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Transcription of Liver X Receptor Is Down-Regulated by 15-Deoxy-Δ12,14-Prostaglandin J2 through Oxidative Stress in Human Neutrophils [Article]
(Public Library of Science, 2012)Liver X receptors (LXRs) are ligand-activated transcription factors of the nuclear receptor superfamily. They play important roles in controlling cholesterol homeostasis and as regulators of inflammatory gene expression ...
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1–42 b -Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death [Article]
(Nature Publishing Group, 2013)1–42 b -Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death L Manterola 1,12 , M Hernando-Rodr ı ́ guez 2,12 , A Ruiz 3,4 , A Apraiz 5 , O Arrizabalaga 5 , L Vello ́ n 6 , E ...
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Glutaredoxins are essential for stress adaptation in the cyanobacterium Synechocystis sp. PCC 6803 [Article]
(Frontiers media, 2013)Glutaredoxins are small redox proteins able to reduce disulfides and mixed disulfides between GSH and proteins. Synechocystis sp. PCC 6803 contains three genes coding for glutaredoxins: ssr2061 (grxA) and slr1562 (grxB) ...
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In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology [Article]
(BioMed Central, 2013)Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies, ...
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Protección antioxidante de un extracto enzimático de orujo de la uva y sus polifenoles mayoritarios sobre la activación de NADPH oxidasa y la inhibición de superóxido dismutasa [Article]
(Sociedad Española de Farmacología: Fundación Teófilo Hernando, 2013) -
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Elongation factor 2-diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions [Article]
(Elsevier, 2013)Elongation factor-2 (eEF2) catalyzes the movement of the ribosome along the mRNA. A single histidine residue in eEF2 (H715) is modified to form diphthamide. A role for eEF2 in cellular stress responses is highlighted by ...
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Molecular Control of the Amount, Subcellular Location and Activity State of Translation Elongation Factor 2 (eEF-2) in Neurons Experiencing Stress [Article]
(Eslsevier, 2013)Eukaryotic elongation factor 2 (eEF-2) is an important regulator of the protein translation machinery wherein it controls the movement of the ribosome along the mRNA. The activity of eEF-2 is regulated by changes in cellular ...
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Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation [Article]
(BioMed Central, 2014)Background: Parkinson’s disease is an irreversible neurodegenerative disease linked to progressive movement disorders and is accompanied by an inflammatory reaction that is believed to contribute to its pathogenesis. ...
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Learning improvement after PI3K activation correlates with de novo formation of functional small spines [Article]
(Frontiers Media S.A., 2014)PI3K activation promotes the formation of synaptic contacts and dendritic spines, morphological features of glutamatergic synapses that are commonly known to be related to learning processes. In this report, we show that ...
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The role of Galectin-3 in α-synuclein-induced microglial activation [Article]
(BioMed Central, 2014)Background: Parkinson ’ s disease (PD) is the most prevalent neurodegenerative motor disorder. The neuropathology is characterized by intraneuronal protein aggregates of α -synuclein and progressive degeneration of ...
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Disruption of Amyloid Plaques Integrity Affects the Soluble Oligomers Content from Alzheimer Disease Brains [Article]
(Public Library of Science, 2014)The implication of soluble Abeta in the Alzheimer's disease (AD) pathology is currently accepted. In fact, the content of soluble extracellular Abeta species, such as monomeric and/or oligomeric Abeta, seems to correlate ...
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Diseño y escalado de un proceso biotecnológico de valorización de suero lácteo mediante la producción de ácido láctico [Article]
(Universidad Pablo de Olavide, 2014)Motivación: La industria quesera genera grandes cantidades de suero lácteo, líquido que queda tras la separación de la grasa y la caseína de la leche en el proceso de producción del queso. El suero lácteo es uno de los ...
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Diagnostic utility of oxidative damage markers for early rheumatoid arthritis in non-smokers and negative anti-CCP patients [Article]
(Gobierno de Navarra, 2014)Fundamento. A pesar del desarrollo de nuevos marcadores y cri- terios diagnósticos para la artritis reumatoide (AR), todavía mu- chos pacientes son diagnosticados tras varios años de síntomas. Los marcadores de estrés ...
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Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia [Article]
(Nature Publishing Group, 2014)The activation of microglia, resident immune cells of the central nervous system, and inflammation-mediated neurotoxicity are typical features of neurodegenerative diseases, for example, Alzheimer's and Parkinson's diseases. ...
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Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal [Article]
(Hindawi Publishing Corporation, 2014)Lipid peroxidation can be described generally as a process under which oxidants such as free radicals attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs). Over the last ...