Browsing Artículos (Bioquímica y Biología Molecular) by Issue Date
Now showing items 21-40 of 144
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Inflammatory animal model for parkinson’s disease: the intranigral injection of LPS induced the inflammatory process along with the selective degeneration of nigrostriatal dopaminergic neurons
(A. Conti and A. Lewen, 2011)We have developed an animal model of degeneration of the nigrostriatal dopaminergic neurons, the neuronal system involved in ...
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How the Local Geometry of the Cu-Binding Site Determines the Thermal Stability of Blue Copper Proteins
(Elsevier, 2011-01)Identifying the factors that govern the thermal resistance of cupredoxins is essential for understanding their folding and ...
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Metformin inhibits glutaminase activity and protects against hepatic encephalopathy
(2012)Aim: To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective ...
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Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
(2012)Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies ...
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Potential use of adipose tissue stem cells in the control of aging
(Federation of Anti-Aging Medicine Societies, 2012)Cell therapy with adult stem cells is a new battle front for the control of aging. Before being used for this purpose, we ...
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Folic acid supplementation: some practical aspects
(Federation of Anti-Aging Medicine Societies, 2012)Since 1956, when Harman first postulated the free radical theory of aging, numerous studies have been carried out to test ...
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Transcription of Liver X Receptor Is Down-Regulated by 15-Deoxy-Δ12,14-Prostaglandin J2 through Oxidative Stress in Human Neutrophils
(Public Library of Science, 2012)Liver X receptors (LXRs) are ligand-activated transcription factors of the nuclear receptor superfamily. They play ...
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Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus
(Springer, 2012)Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease ...
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Elongation factor 2-diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions
(Elsevier, 2013)Elongation factor-2 (eEF2) catalyzes the movement of the ribosome along the mRNA. A single histidine residue in eEF2 (H715) ...
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Molecular Control of the Amount, Subcellular Location and Activity State of Translation Elongation Factor 2 (eEF-2) in Neurons Experiencing Stress
(Eslsevier, 2013)Eukaryotic elongation factor 2 (eEF-2) is an important regulator of the protein translation machinery wherein it controls ...
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Glutaredoxins are essential for stress adaptation in the cyanobacterium Synechocystis sp. PCC 6803
(Frontiers media, 2013)Glutaredoxins are small redox proteins able to reduce disulfides and mixed disulfides between GSH and proteins. Synechocystis ...
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In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology
(BioMed Central, 2013)Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) ...
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Protección antioxidante de un extracto enzimático de orujo de la uva y sus polifenoles mayoritarios sobre la activación de NADPH oxidasa y la inhibición de superóxido dismutasa
(Sociedad Española de Farmacología: Fundación Teófilo Hernando, 2013) -
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1–42 b -Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death
(Nature Publishing Group, 2013)1–42 b -Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death L Manterola 1,12 , M Hernando-Rodr ı ...
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Stress and inflammation: a detrimental combination in the development of neurodegenerative disease
(Smart Science and Technology, 2014)Chronic stress accelerates the appearance of some neurodegenerative disorders, such as Alzheimer’s disease and Parkinson´s ...
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Diseño y escalado de un proceso biotecnológico de valorización de suero lácteo mediante la producción de ácido láctico
(Universidad Pablo de Olavide, 2014)Motivación: La industria quesera genera grandes cantidades de suero lácteo, líquido que queda tras la separación de la ...
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Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal
(Hindawi Publishing Corporation, 2014)Lipid peroxidation can be described generally as a process under which oxidants such as free radicals attack lipids ...