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Mostrando ítems 1-10 de 311
Artículo
Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition
(Wiley-Blackwell, 2009)
Dysfunctions of the ubiquitin proteasome system (UPS) have been proposed to be involved in the aetiology and/or progression of several age-related neurodegenerative disorders. However, the mechanisms linking proteasome ...
Artículo
Effect of oxidative stress, produced by cumene hydroperoxide, on the various steps of protein synthesis. Modifications of elongation factor-2
(American Society for Biochemistry and Molecular Biology, 1996)
We have studied the effect of oxidative stress on protein synthesis in rat liver. Cumene hydroperoxide (CH) was used as an oxidant agent. The approach used was to determine the ribosomal state of aggregation and the time ...
Tesis Doctoral
Evaluación de la influencia de la exposición laboral a fitosanitarios en mujeres que recogen verduras: posibles consecuencias sobre su salud
(2021-04-14)
Una de las misiones fundamentales de la figura del Técnico Superior de Prevención de Riesgos Laborales es preguntarse si, en ambientes laborales donde la exposición a distintos tipos de productos es indirecta, dicha ...
Artículo
Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism
(BioMed Central, 2015)
Background We have uncovered a caspase-dependent (caspase-8/caspase-3/7) signaling governing microglia activation and associated neurotoxicity. Importantly, a profuse non-nuclear activation of cleaved caspases 8 and 3 was ...
Patente
Obtención de un extracto proteico mediante hidrólisis enzimática a partir de hojas de tabaco y su aplicación como fertilizante.
(Oficina Española de Patentes y Marcas , 2012-12-27)
El objeto de la invención es obtener un producto a partir de hojas de tabaco (frescas y/o secas) desechadas para la fabricación del propio tabaco que actúen como en el campo agronómico como biofertilizante/bioestimulante. ...
Artículo
Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
(Frontiers Media, 2021)
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by initial memory impairments that progress to dementia. In this sense, synaptic dysfunction and loss have been established as the pathological ...
Artículo
Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-β-Induced Neuronal Death
(IOS Press, 2016-06-07)
Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain pathologies. We recently showed that an astrocyte-specific intracellular signaling pathway involving ...
Tesis Doctoral
Los citocromos b-564 de mitocondrias y b-559 de cloroplastos como sistemas transductores de energía redox en ácido - base en la respiración y en la fotosíntesis
(1984-12-21)
En este trabajo se ha tratado de profundizar en el posible papel en la transducción de la energía del citocromo b-564 de la cadena respiratoria, así como del citocromo b-559 de la cadena fotosintética. Para ello, se ha ...
Artículo
In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology
(BioMed Central, 2013)
Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies, ...
Artículo
Altered Intracellular Ca2+ Homeostasis in Nerve Terminals of Severe Spinal Muscular Atrophy Mice
(SOC NEUROSCIENCE, 2010)
Low levels of survival motor neuron (SMN) protein result in spinal muscular atrophy (SMA), a severe genetic disease characterized by motor impairment and premature lethality. Although SMN is a ubiquitous protein, motor ...