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PhD Thesis
Evaluación de la influencia de la exposición laboral a fitosanitarios en mujeres que recogen verduras: posibles consecuencias sobre su salud
(2021-04-14)
Una de las misiones fundamentales de la figura del Técnico Superior de Prevención de Riesgos Laborales es preguntarse si, en ambientes laborales donde la exposición a distintos tipos de productos es indirecta, dicha ...
Article
Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
(Frontiers Media, 2021)
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by initial memory impairments that progress to dementia. In this sense, synaptic dysfunction and loss have been established as the pathological ...
Article
A metagenome-wide association study of HIV disease progression in HIV controllers
(Elsevier, 2023)
Some HIV controllers experience immunologic progression with CD4+ T cell decline. We aimed to identify genetic factors associated with CD4+ T cell lost in HIV controllers. A total of 561 HIV controllers were included, 442 ...
Article
Niveles de vitamina D en sangre materna y su relación con el consumo de pescado y los parámetros antropométricos de los recién nacidos en una cohorte de parejas madre/hijos de Sevilla
(Elsevier, 2023-09)
Introducción Comparar los niveles de vitamina D maternos con la zona de residencia o el consumo de pescado, así como su relación con el peso, la longitud y el perímetro craneal de los bebés. Materiales y métodos Cohorte ...
Article
Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors
(American Society for Clinical Investigation, 2022)
New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly potentiated by concomitant therapy with the ...
Article
Galectin-3 is upregulated in frontotemporal dementia patients with subtype specificity
(Wiley, 2023-11)
INTRODUCTION Neuroinflammation is a major contributor to the progression of frontotemporal dementia (FTD). Galectin-3 (Gal-3), a microglial activation regulator, holds promise as a therapeutic target and potential biomarker. ...
PhD Thesis
Posible papel diferencial de la autofagia en respuesta al estrés proteico en microglía y neuronas
(2022-03-18)
En esta tesis doctoral hemos afrontado el estudio de mecanismos implicados en el mantenimiento de la proteostasis en dos tipos diferentes de células del sistema nervioso: microglía y neuronas. Para ello, se ha usado un ...
Article
Cell Death Related Proteins Beyond Apoptosis in the CNS
(Frontiers Media S.A., 2022)
Cell death related (CDR) proteins are a diverse group of proteins whose original function was ascribed to apoptotic cell death signaling. Recently, descriptions of non-apoptotic functions for CDR proteins have increased. ...
Article
Galectin-3 shapes toxic alpha-synuclein strains in Parkinson's disease.
(Springer, 2023)
Parkinson’s Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions called Lewy bodies (LB) and degeneration of dopaminergic neurons in the substantia nigra (SN). Aggregated ...
Article
Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells
(Frontiers Media, 2023)
The subventricular zone (SVZ) is a brain region that contains neural stem cells and progenitor cells (NSCs/NPCs) from which new neurons and glial cells are formed during adulthood in mammals. Recent data indicate that ...