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Tesis Doctoral
Estrategias de selección espermática en humanos: impacto en la calidad del ADN y en el éxito reproductivo.
(2019-03-15)
El objetivo de esta Tesis Doctoral es determinar qué estrategias muestran mayor eficacia para seleccionar en una muestra seminal al espermatozoide más adecuado que permita el éxito clínico en los tratamientos de reproducción ...
Artículo
Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers
(American Chemical Society, 2019)
The formation of misfolded protein oligomers during early stages of amyloid aggregation and the activation of neuroinflammatory responses are two key events associated with neurodegenerative diseases. Although it has been ...
Artículo
Human amniotic membrane conditioned medium inhibits proliferation and modulates related microRNAs expression in hepatocarcinoma cell
(2019-10-02)
The placental stem cells have called the focus of attention for their therapeutic potential to treat diferent diseases, including cancer. There is plenty evidence about the antiproliferative, antiangiogenic and ...
Artículo
Proteoglycans involved in bidirectional communication between mast cells and hippocampal neurons
(BMC, 2019-05-20)
Background: Mast cells (MCs) in the brain can respond to environmental cues and relay signals to neurons that may directly influence neuronal electrical activity, calcium signaling, and neurotransmission. MCs also ...
Artículo
Circulating regulatory T cells from breast cancer patients in response to neoadjuvant chemotherapy
(Amer Publ Co, 2019)
Background: Immune escape of tumor cells is a new hallmark of cancer in general, and breast cancer, in particular. Previous studies have demonstrated that the immunological profile in peripheral blood may be a prognostic ...
Artículo
Obesity and Breast Cancer: Role of Leptin
(2019-07-18)
Obesity-related breast cancer is an important threat that affects especially post-menopausal women. The link between obesity and breast cancer seems to be relying on the microenvironment generated at adipose tissue level, ...
Tesis Doctoral
Factores inmunológicos asociados a la aparición de eventos no sida y al control espontáneo de la infección por el VIH.
(2019-02-26)
La presente Tesis Doctoral se ha centrado en estudiar uno de los principales problemas clínicos de los pacientes infectados por VIH bajo tratamiento antirretroviral combinado (TARc), que es la prevalencia y morbi-mortalidad ...
Artículo
Temporal expression patterns of the melatoninergic system in the human thymus of children
(Elsevier BV, 2019)
Objectives: To obtain greater knowledge of the extra-pineal sources of melatonin during development, the amount of indolamine and the expression levels of the last two enzymes involved in its biosynthesis, Arylalkylamine ...
Artículo
Repeat Instability in the Fragile X-Related Disorders: Lessons from a Mouse Model
(Multidisciplinary Digital Publishing Institute (MDPI), 2019-03-01)
The fragile X-related disorders (FXDs) are a group of clinical conditions that result primarily from an unusual mutation, the expansion of a CGG-repeat tract in exon 1 of the FMR1 gene. Mouse models are proving useful for ...
Artículo
Minor compounds from virgin olive oil attenuate LPS-induced inflammation via visfatin-related gene modulation on primary human monocytes
(Wiley-Blackwell, 2019)
We have analyzed the effects of minor compounds found in the unsaponifiable fraction (UF) and in the phenolic fraction (PF) of virgin olive oil (VOO) on LPS-induced inflammatory response via visfatin modulation in human ...