Buscar
Mostrando ítems 1-9 de 9
Artículo
Role of leptin in non-alcoholic fatty liver disease
(MDPI, 2021-06-30)
Non-alcoholic fatty liver disease (NAFLD), which affects about a quarter of the global population, poses a substantial health and economic burden in all countries, yet there is no approved pharmacotherapy to treat this ...
Artículo
Possible Role of Leptin in Atopic Dermatitis: A Literature Review
(MDPI, 2021-11-05)
Atopic dermatitis (AD) is the most frequent chronic inflammatory skin disease, and its incidence has been rapidly increasing in developed countries in the last years. AD presents a high degree of heterogeneity due to biases ...
Artículo
Obesity as a Risk Factor for Dementia and Alzheimer’s Disease: The Role of Leptin
(MDPI AG, 2022)
Obesity is a growing worldwide health problem, affecting many people due to excessive saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine secreted by adipose tissue that increases ...
Artículo
Leptin action in normal and pathological pregnancies
(2018)
Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the ...
Artículo
Obesity and Breast Cancer: Role of Leptin
(2019-07-18)
Obesity-related breast cancer is an important threat that affects especially post-menopausal women. The link between obesity and breast cancer seems to be relying on the microenvironment generated at adipose tissue level, ...
Artículo
Sam68 Mediates the Activation of Insulin and Leptin Signalling in Breast Cancer Cells
(Public Library Science, 2016)
Obesity is a well-known risk factor for breast cancer development in postmenopausal women. High insulin and leptin levels seem to have a role modulating the growth of these tumours. Sam68 is an RNA-binding protein with ...
Artículo
Sam68 mediates leptin signaling and action in human granulosa cells: possible role in leptin resistance in PCOS
(BioScientifica, 2020)
Introduction: Polycystic ovary syndrome (PCOS) is a complex metabolic disorder associated with ovulatory dysfunction, hyperandrogenism, obesity, and insulin resistance, that leads to subfertility. Sam68 is an RNA-binding ...
Artículo
Role of leptin in inflammation and vice versa
(2020-08-16)
Inflammation is an essential immune response for the maintenance of tissue homeostasis. In a general sense, acute and chronic inflammation are different types of adaptive response that are called into action when other ...
Artículo
Role of Leptin as a Link between Asthma and Obesity: A Systematic Review and Meta-Analysis
(MDPI, 2022-12-29)
Asthma and obesity are considered as highly prevalent diseases with a great impact on public health. Obesity has been demonstrated to be an aggravating factor in the pathogenesis of asthma. Adipose tissue secretes ...