Browsing Artículos (Instituto de Investigaciones Químicas (IIQ) – CIC Cartuja) by Subject "Gaucher disease"
Now showing items 1-4 of 4
-
Article
Conformationally-locked N -glycosides: Exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease
(Elsevier, 2015)Pyranoid-type glycomimetics having a cis-1,2-fused glucopyranose–2-alkylsulfanyl-1,3-oxazoline (Glc-PSO) structure exhibit ...
-
Article
GCase Enhancers: A Potential Therapeutic Option for Gaucher Disease and Other Neurological Disorders
(MDPI, 2022)Pharmaceutical chaperones (PCs) are small compounds able to bind and stabilize misfolded proteins, allowing them to recover ...
-
Article
Pharmacological chaperone therapy for Gaucher disease: A patent review
(Taylor & Francis, 2011)Introduction: Mutations in the gene encoding for acid β-glucosidase (β-glucocerebrosidase, GlcCerase) are seen in Gaucher ...
-
Article
Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human -Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease
(Molecular Diversity Preservation International, 2018)A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ...