Now showing items 1-4 of 4
Intracellular proton pumps as targets in chemotherapy: V-ATPases and cancer [Article]
(Bentham Science Publishers, 2012)
Cancer cells show a metabolic shift that makes them overproduce protons; this has the potential to disturb the cellular acid-base homeostasis. However, these cells show cytoplasmic ...
Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation [Article]
Tyrosine nitration is one of the most common post-transcriptional modifications of proteins, so affecting their structure and function. Human cytochrome c, with five tyrosine residues, is an excellent case study as it is ...
A comparison between nuclear dismantling during plant and animal programmed cell death [Article]
Programmed cell death (PCD) is a process of organized destruction of cells, essential for the development and maintenance of cellular homeostasis of multicellular organisms. Cells undergoing PCD begin a degenerative process ...
Structural and Functional Analysis of Novel Human Cytochrome c Targets in Apoptosis [Article]
(American Society for Biochemistry and Molecular Biology, 2014)
Since the first description of apoptosis four decades ago, great efforts have been made to elucidate, both in vivo and in vitro, the molecular mechanisms involved in its regulation. Although the role of cytochrome c during ...